Tchem AURKA Aurora kinase A

Protein Summary

Description

Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis. The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14965
• E1P5F9
• O60445
• O75873
• Q9BQD6
• Q9UPG5

Gene Name

• AURKA

Ensembl ID

• ENST00000312783
• ENSP00000321591
• ENSG00000087586
• ENST00000347343
• ENSP00000216911
• ENST00000371356
• ENSP00000360407
• ENST00000395911
• ENSP00000379247
• ENST00000395913
• ENSP00000379249
• ENST00000395914
• ENSP00000379250
• ENST00000395915
• ENSP00000379251

Symbol

• AIK
• AIRK1
• ARK1
• AURA
• AYK1
• BTAK
• IAK1
• STK15
• STK6
• AIK
• ARK1
• AURA
• BTAK
• STK6
• STK7
• STK15
• PPP1R47

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
interacting protein	0.99
biological term	0.98
molecular function	0.98
transcription factor perturbation	0.96

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Aurora Kinase A

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Aur Family / Aurora Kinase A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1114.4   (req: < 5)

Gene RIFs: 659   (req: <= 3)

Antibodies: 972   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1114.4   (req: >= 5)

Gene RIFs: 659   (req: > 3)

Antibodies: 972   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1097

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2