Tbio UQCRQ Cytochrome b-c1 complex subunit 8

Protein Summary

Description

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone. This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14949
• Q5FVE2
• Q9BV88
• Q9T2V7

Gene Name

• UQCRQ

Ensembl ID

• ENST00000378665
• ENSP00000367934
• ENSG00000164405
• ENST00000378667
• ENSP00000367936
• ENST00000378670
• ENSP00000367939

Symbol

• QPC
• QCR8
• QP-C
• UQCR7
• MC3DN4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
kinase perturbation	0.95
histone modification site profile	0.9
virus perturbation	0.85
transcription factor binding site profile	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.57   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.57   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0