Tbio TIMM23 Mitochondrial import inner membrane translocase subunit Tim23

Protein Summary

Description

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• O14925
• Q53FF8
• Q5T1E6
• Q6P5S5

Gene Name

• TIMM23

Ensembl ID

• ENST00000580018
• ENSP00000464522
• ENSG00000265354

Symbol

• TIM23
• TIM23

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
virus perturbation	0.98
kinase perturbation	0.97
histone modification site profile	0.79
cellular component	0.78

Protein Classes

PANTHER Classes

Protein / Transporter / Amino Acid Transporter / Mitochondrial Import Inner Membrane Translocase Subunit Tim23

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.58   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.58   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0