MSTN
Growth/differentiation factor 8
Protein Summary
Acts specifically as a negative regulator of skeletal muscle growth. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]
- ENST00000260950
- ENSP00000260950
- ENSG00000138379
- GDF8
- GDF8
- MSLHP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
gene perturbation | 0.85 | ||
protein domain | 0.85 | ||
biological term | 0.83 | ||
cell type or tissue | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2194.61 (req: < 5)
Gene RIFs: 185 (req: <= 3)
Antibodies: 732 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2194.61 (req: >= 5)
Gene RIFs: 185 (req: > 3)
Antibodies: 732 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 38
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1