Tbio HSD17B6 17-beta-hydroxysteroid dehydrogenase type 6

Protein Summary

Description

NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. The oxidoreductase activity can convert 3 alpha-adiol to dihydrotestosterone, while the epimerase activity can convert androsterone to epi-androsterone. Both reactions use NAD+ as the preferred cofactor. This gene is a member of the retinol dehydrogenase family. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• O14756
• O43275
• 17-beta-HSD 6

Gene Name

• HSD17B6

Ensembl ID

• ENST00000322165
• ENSP00000318631
• ENSG00000025423
• ENST00000554150
• ENSP00000452273
• ENST00000554643
• ENSP00000451406
• ENST00000555159
• ENSP00000450698
• ENST00000555805
• ENSP00000451753

Symbol

• RODH
• SDR9C6
• HSE
• RODH
• SDR9C6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.67
gene perturbation	0.62
protein domain	0.58
cellular component	0.55
small molecule perturbation	0.55

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / 17-beta-hydroxysteroid Dehydrogenase Type 6

Protein / Oxidoreductase / Dehydrogenase / 17-beta-hydroxysteroid Dehydrogenase Type 6

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / 17-beta-hydroxysteroid Dehydrogenase Type 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.24   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.24   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0