| Tchem | Telomerase reverse transcriptase |
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| cystic fibrosis | 1670 | 5.03646097911099E-6 |
| medulloblastoma, large-cell | 6234 | 0.00161355017678676 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pulmonary Fibrosis | 66 | 3.941 | 2.0 |
| Adenocarcinoma | 115 | 0.0 | 2.0 |
| Brain cancer | 24 | 0.0 | 2.0 |
| Breast cancer | 3099 | 0.0 | 2.0 |
| Malignant glioma | 23 | 0.0 | 2.0 |
| Prostate cancer | 172 | 0.0 | 2.0 |
| Testicular cancer | 24 | 0.0 | 2.0 |
| interstitial lung disease | 292 | 0.0 | 2.0 |
| lung cancer | 4473 | 0.0 | 2.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Idiopathic pulmonary fibrosis | 21 | 0.0 | 5.0 |
| Disease | log2 FC | p |
|---|---|---|
| medulloblastoma, large-cell | 1.400 | 0.002 |
| cystic fibrosis | -2.800 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG Inparanoid |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| S.cerevisiae | EggNOG Inparanoid |
CHEMBL274096
pIC50 6.00
CHEMBL2297962
pIC50 6.00
CHEMBL239789
pEC50 6.00
CHEMBL421825
pIC50 6.00
CHEMBL3109739
pIC50 6.00
CHEMBL297453
pIC50 6.00
CHEMBL222541
pIC50 6.00
CHEMBL3786231
pIC50 6.01
CHEMBL2298059
pIC50 6.02
CHEMBL3115514
pIC50 6.04
CHEMBL3423397
pIC50 6.04
CHEMBL3323504
pIC50 6.05
CHEMBL2333209
pIC50 6.05
CHEMBL2298054
pIC50 6.05
CHEMBL443683
pIC50 6.05
CHEMBL3330784
pIC50 6.05
CHEMBL2312629
pIC50 6.05
CHEMBL239791
pEC50 6.06
CHEMBL1162066
pEC50 6.07
CHEMBL336434
pIC50 6.08
| PMID | Text |
|---|---|
| 27455559 | The FGFR3, PIK3CA, TERT mutations, along with aberrant DNA methylation patterns, can serve as reliable genetic markers for the diagnosis of urinary bladder cancer. (Review) |
| 27273963 | Review/Meta-analysis: TERT rs2736098 variant may modify the susceptibility to cancer. |
| 27077147 | TERT promoter mutations may be a specific marker of the clinically aggressive forms of adrenocortical carcinoma |
| 27064992 | the prevalence and clinicopathological associations of BRAF V600E and TERT promoter mutations in Chinese PTC patients |
| 27016301 | This study found that hTERT polymorphisms were associated with risk of gastric cancer. |
| 26956036 | PPARgamma might inhibit the proliferation and migration of GC cell lines through suppressing the expression of TERT and ENAH |
| 26953344 | loss of ARID1A protein expression caused by inactivating mutations reactivates TERT transcriptional activity and confers a survival advantage of tumor cells by maintaining their telomeres. |
| 26913901 | Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer |
| 26892657 | telomerase may be involved in the phenomenon of regression, as melanomas with regression are less frequently associated with TERT mutations than melanomas without regression |
| 26887940 | Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases. |
| More... |
MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPS 1 - 70 FRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLL 71 - 140 LRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREA 141 - 210 GVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAE 211 - 280 EATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSL 281 - 350 RPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVT 351 - 420 PAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRN 421 - 490 TKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSF 491 - 560 FYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGL 561 - 630 RPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQ 631 - 700 DPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQ 701 - 770 PYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTL 771 - 840 LCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVE 841 - 910 DEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRL 911 - 980 KCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAK 981 - 1050 NAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAAN 1051 - 1120 PALPSDFKTILD 1121 - 1132 //
| PMID | Year | Title |
|---|---|---|
| 27455559 | 2016 | [THE SOMATIC MUTATIONS AND ABERRANT METHYLATION AS POTENTIAL GENETIC MARKERS OF URINARY BLADDER CANCER]. |
| 27273963 | New evidence of TERT rs2736098 polymorphism and cancer risk: an updated meta-analysis. | |
| 27077147 | [Telomerase reverse transcriptase (TERT) promoter mutations in the tumors of human endocrine organs: Biological and prognostic value]. | |
| 27064992 | 2016 | BRAF V600E and TERT Promoter Mutations in Papillary Thyroid Carcinoma in Chinese Patients. |
| 27016301 | 2016 | Polymorphisms in human telomerase reverse transcriptase (hTERT) gene and susceptibility to gastric cancer in a Turkish population: Hospital-based case-control study. |
| 26956036 | 2016 | Constitutive expression of PPAR? inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/?-Catenin signaling pathway downstream target genes TERT and ENAH. |
| 26953344 | 2016 | Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells. |
| 26913901 | 2016 | Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer. |
| 26892657 | 2016 | Lack of TERT promoter mutations in melanomas with extensive regression. |
| 26887940 | 2016 | Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases. |
| More... |
