Property Summary

NCBI Gene PubMed Count 24
PubMed Score 246.06
PubTator Score 25.69

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
atypical teratoid / rhabdoid tumor 4369 4.80713276134905E-8
ulcerative colitis 2087 1.16870737724162E-5
ovarian cancer 8492 1.33086312854013E-5
medulloblastoma, large-cell 6234 2.15841548086961E-5
Atopic dermatitis 944 5.52459239461222E-5
intraductal papillary-mucinous neoplasm (IPMN) 3289 8.90936491879506E-5
adult high grade glioma 2148 1.53185184374381E-4
osteosarcoma 7933 5.21553999352741E-4
psoriasis 6685 6.88681386722553E-4
spina bifida 1064 0.0412572915265152

Expression

  Differential Expression (10)

Disease log2 FC p
psoriasis 1.500 0.001
osteosarcoma 1.266 0.001
atypical teratoid / rhabdoid tumor -1.400 0.000
medulloblastoma, large-cell -1.400 0.000
Atopic dermatitis -1.100 0.000
intraductal papillary-mucinous neoplasm ... 2.200 0.000
adult high grade glioma -1.400 0.000
spina bifida -1.094 0.041
ulcerative colitis -1.100 0.000
ovarian cancer 1.600 0.000

Synonym

Accession O14734 O15261 Q17RX4 Acyl-CoA thioesterase 8
Symbols hTE
NAP1
PTE1
PTE2
PTE-1
PTE-2
HNAACTE
hACTE-III

Gene

PANTHER Protein Class (2)

  Ortholog (16)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA Inparanoid
Opossum EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid
C. elegans OMA EggNOG
C. elegans OMA Inparanoid
S.cerevisiae OMA EggNOG Inparanoid

Gene RIF (12)

PMID Text
26423947 HIV-1 Nef (from strains NA7 and NL4-3 only) directly interacts with ACOT8 in 293T cells and this interaction is mediated by residues in the Nef core domain as shown by FACS-Forster resonance energy transfer (FRET)-based methods
24788990 In summary, lipolytic enzyme ACOT8 is frequently upregulated in HCC clinical specimens. More importantly, ACOT8 silencing leads to inhibition of cell growth in HCC in vitro.
23540296 Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma.
22190034 HIV-1 Nef (from strains NA7 and NL4-3 only) directly interacts with ACOT8 in 293T cells and this interaction is mediated by residues in the Nef core domain as shown by FACS-Forster resonance energy transfer (FRET)-based methods
21824805 HIV-1 Nef (from strains NA7 and NL4-3 only) directly interacts with ACOT8 in 293T cells and this interaction is mediated by residues in the Nef core domain as shown by FACS-Forster resonance energy transfer (FRET)-based methods
17624024 An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol.
16335799 SREBP2 modulates brain palmitoyl-coa hydrolase gene transcription.
16141203 ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids
10807905 HIV-1 Nef (from strains NA7 and NL4-3 only) directly interacts with ACOT8 in 293T cells and this interaction is mediated by residues in the Nef core domain as shown by FACS-Forster resonance energy transfer (FRET)-based methods
10799608 HIV-1 Nef (from strains NA7 and NL4-3 only) directly interacts with ACOT8 in 293T cells and this interaction is mediated by residues in the Nef core domain as shown by FACS-Forster resonance energy transfer (FRET)-based methods
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AA Sequence

MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKS      1 - 70
VSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQF     71 - 140
SMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVR    141 - 210
ARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWA    211 - 280
GGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL                                   281 - 319
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Text Mined References (26)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
24788990 2014 Fatty acid metabolic enzyme acyl-CoA thioesterase 8 promotes the development of hepatocellular carcinoma.
23540296 2013 Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma.
22190034 2011 Global landscape of HIV-human protein complexes.
21269460 2011 Initial characterization of the human central proteome.
20178365 2010 A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities.
17624024 2007 Nafamostat is hydrolysed by human liver cytosolic long-chain acyl-CoA hydrolase.
16940157 2006 Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs.
16756494 2006 Biochemistry of mammalian peroxisomes revisited.
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