| Tbio | Apoptotic protease-activating factor 1 |
Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma, Renal Cell | 124 | 0.0 | 0.0 |
| Carcinoma, Transitional Cell | 32 | 0.0 | 0.0 |
| Craniofacial Abnormalities | 151 | 0.0 | 0.0 |
| Eye Abnormalities | 35 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Retinal Detachment | 51 | 0.0 | 0.0 |
| Skin Abnormalities | 37 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Major Depressive Disorder | 301 |
| Renal Cell Carcinoma | 214 |
| Unipolar Depression | 250 |
| Disease | Target Count | P-value |
|---|---|---|
| hepatocellular carcinoma | 547 | 1.9e-06 |
| osteosarcoma | 7950 | 5.0e-06 |
| adrenocortical carcinoma | 1428 | 3.2e-05 |
| pancreatic carcinoma | 562 | 1.8e-04 |
| pancreatic cancer | 2398 | 1.8e-04 |
| group 3 medulloblastoma | 4104 | 4.8e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.0e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 8.5e-03 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.173 | 3.2e-05 |
| group 3 medulloblastoma | 1.700 | 4.8e-04 |
| hepatocellular carcinoma | 1.100 | 1.9e-06 |
| intraductal papillary-mucinous adenoma (... | 1.300 | 6.0e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.800 | 8.5e-03 |
| osteosarcoma | -1.568 | 5.0e-06 |
| pancreatic cancer | 1.100 | 1.8e-04 |
| pancreatic carcinoma | 1.100 | 1.8e-04 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG |
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVS 1 - 70 FYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKL 71 - 140 SKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDE 141 - 210 SFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVV 211 - 280 PVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQF 281 - 350 KRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVN 351 - 420 KSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYH 421 - 490 MASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPF 491 - 560 PNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRI 561 - 630 ASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 631 - 700 QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLW 701 - 770 DATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHH 771 - 840 STIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE 841 - 910 TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGD 911 - 980 ENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 981 - 1050 RLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPL 1051 - 1120 HELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGK 1121 - 1190 MLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE 1191 - 1248 //
