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Tchem
PTGES
Prostaglandin E synthase

Protein Summary
Description
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340607
  • ENSP00000342385
  • ENSG00000148344

Symbol
  • MGST1L1
  • MPGES1
  • PGES
  • PIG12
  • PGES
  • MPGES
  • PIG12
  • PP102
  • PP1294
  • MGST-IV
  • MGST1L1
  • TP53I12
  • mPGES-1
  • MGST1-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
PubMedID
0.82
biological term
0.8
disease
0.75
small molecule perturbation
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 887.4   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 887.4   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1105
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2