Tclin KCNK3 Potassium channel subfamily K member 3

Protein Summary

Description

pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. This gene encodes a member of the superfamily of potassium channel proteins that contain two pore-forming P domains. The encoded protein is an outwardly rectifying channel that is sensitive to changes in extracellular pH and is inhibited by extracellular acidification. Also referred to as an acid-sensitive potassium channel, it is activated by the anesthetics halothane and isoflurane. Although three transcripts are detected in northern blots, there is currently no sequence available to confirm transcript variants for this gene. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• O14649
• Q53SU2

Gene Name

• KCNK3

Ensembl ID

• ENST00000302909
• ENSP00000306275
• ENSG00000171303

Symbol

• TASK
• TASK1
• OAT1
• PPH4
• TASK
• TBAK1
• K2p3.1
• TASK-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
gene perturbation	0.81
disease perturbation	0.68
microRNA	0.68
biological process	0.67

Protein Classes

DTO Classes

Protein / Ion Channel / Two Pore Domain Potassium Channel Family / Potassium Channel Subfamily K Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.88   (req: < 5)

Gene RIFs: 72   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.88   (req: >= 5)

Gene RIFs: 72   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 522

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7