Tchem CIT Citron Rho-interacting kinase

Protein Summary

Description

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2. This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O14578
• Q2M5E1
• Q6XUH8
• Q86UQ9
• Q9UPZ7
• CRIK

Gene Name

• CIT

Ensembl ID

• ENST00000261833
• ENSP00000261833
• ENSG00000122966
• ENST00000392521
• ENSP00000376306
• ENST00000612548
• ENSP00000482318

Symbol

• CRIK
• KIAA0949
• STK21
• CITK
• CRIK
• STK21
• MCPH17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
drug perturbation	0.96
ligand (protein) perturbation	0.96
small molecule	0.96

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Agc Group / Dmpk Family / Citron Rho-interacting Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.79   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 163   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.79   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0