Property Summary

NCBI Gene PubMed Count 34
PubMed Score 6.14
PubTator Score 22.93

Knowledge Summary

Patent (163,984)

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
non-small cell lung carcinoma 413 1.09286437066071E-15
posterior fossa group A ependymoma 1511 1.27219004207023E-10
ovarian cancer 8492 1.25500031821925E-7
malignant mesothelioma 3163 4.72148992498579E-7
atypical teratoid / rhabdoid tumor 4369 4.92343642367834E-7
inflammatory breast cancer 404 2.00625988520928E-4
breast carcinoma 1614 6.08447791224827E-4
primitive neuroectodermal tumor 3031 6.55345787438421E-4
medulloblastoma, large-cell 6234 0.00101528574936392
glioblastoma 5572 0.00170511640344222
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00234938756994385
Pick disease 1893 0.00622288147566138
lung adenocarcinoma 2714 0.00647833126797603
adult high grade glioma 2148 0.0104762699547564
subependymal giant cell astrocytoma 2287 0.0282535496991673
group 3 medulloblastoma 2254 0.0393535322842821
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Microcephaly 149 0.0 4.0

Expression

Synonym

Accession O14578 Q2M5E1 Q6XUH8 Q86UQ9 Q9UPZ7 CRIK
Symbols CITK
CRIK
STK21
MCPH17

Gene

CIT

  Ortholog (11)

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
1982 other 0 / 0 / 0 Kinase inhibition selectivity assay for compound SID-48409448

Gene RIF (20)

PMID Text
26524911 HIV-1 infection upregulates citK expression at the transcriptional level
25665131 The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis.
23444367 Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.
22761715 High CIT expression is associated with prostate cancer.
22293177 p27 has a role in cytokinesis via the regulation of citron-K activity
21849473 CIT-K is a crucial abscission regulator that may promote midbody stability through active RhoA and anillin.
21748597 Hrs inhibits HIV-1 production by inhibiting citron kinase-mediated exocytosis.
21748597 Ectopic expression of citron kinase leads to the formation of cytoplasmic structures containing citron kinase and HIV-1 Gag proteins
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
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AA Sequence

MLKFKYGARNPLDAGAAEPIASRASRLNLFFQGKPPFMTQQQMSPLSREGILDALFVLFEECSQPALMKI      1 - 70
KHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVS     71 - 140
FFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVH    141 - 210
SVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTY    211 - 280
GLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLK    281 - 350
FEGLCCHPFFSKIDWNNIRNSPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQLSPSGFSGEELPFVGFS    351 - 420
YSKALGILGRSESVVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKE    421 - 490
VELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ    491 - 560
VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAKLEKI    561 - 630
NAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKH    631 - 700
REAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAM    701 - 770
DSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKI    771 - 840
SHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTE    841 - 910
LEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGA    911 - 980
NDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALNDELLEKERQWEAWRSVL    981 - 1050
GDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDK   1051 - 1120
LNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTE   1121 - 1190
RSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNE   1191 - 1260
LKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAM   1261 - 1330
SLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCH   1331 - 1400
PKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVPRNNKRGQQGWDRKYIVL   1401 - 1470
EGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRT   1471 - 1540
LYLLAPSFPDKQRWVTALESVVAGGRVSREKAEADAKLLGNSLLKLEGDDRLDMNCTLPFSDQVVLVGTE   1541 - 1610
EGLYALNVLKNSLTHVPGIGAVFQIYIIKDLEKLLMIAGEERALCLVDVKKVKQSLAQSHLPAQPDISPN   1611 - 1680
IFEAVKGCHLFGAGKIENGLCICAAMPSKVVILRYNENLSKYCIRKEIETSEPCSCIHFTNYSILIGTNK   1681 - 1750
FYEIDMKQYTLEEFLDKNDHSLAPAVFAASSNSFPVSIVQVNSAGQREEYLLCFHEFGVFVDSYGRRSRT   1751 - 1820
DDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSYQ   1821 - 1890
DKLRVICCKGNLVKESGTEHHRGPSTSRSSPNKRGPPTYNEHITKRVASSPAPPEGPSHPREPSTPHRYR   1891 - 1960
EGRTELRRDKSPGRPLEREKSPGRMLSTRRERSPGRLFEDSSRGRLPAGAVRTPLSQVNKVWDQSSV      1961 - 2027
//

Text Mined References (46)

PMID Year Title
27453578 2016 Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly.
26524911 2015 [Mechanism Underlying Increased Expression of a Member of the Serine/Threonine Kinase Family (Citron kinase) Induced by HIV-1 Infection].
25665131 2015 Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis.
23444367 2013 Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22761715 2012 Identification of kinases regulating prostate cancer cell growth using an RNAi phenotypic screen.
22293177 2012 p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.
21849473 2011 Citron kinase controls abscission through RhoA and anillin.
21748597 2011 Hrs inhibits citron kinase-mediated HIV-1 budding via its FYVE domain.
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