Tbio SDHD Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Protein Summary

Description

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). This gene encodes a member of complex II of the respiratory chain, which is responsible for the oxidation of succinate. The encoded protein is one of two integral membrane proteins anchoring the complex to the matrix side of the mitochondrial inner membrane. Mutations in this gene are associated with the formation of tumors, including hereditary paraganglioma. Transmission of disease occurs almost exclusively through the paternal allele, suggesting that this locus may be maternally imprinted. There are pseudogenes for this gene on chromosomes 1, 2, 3, 7, and 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Uniprot Accession IDs

• O14521
• A6ND90
• B3KQQ8
• E9PIC0
• E9PIG3
• E9PQI9
• Q53XW5
• Q6IRW2
• CybS

Gene Name

• SDHD

Ensembl ID

• ENST00000375549
• ENSP00000364699
• ENSG00000204370
• ENST00000525291
• ENSP00000436669
• ENST00000526592
• ENSP00000432005
• ENST00000528048
• ENSP00000436217
• ENST00000614349
• ENSP00000480666

Symbol

• SDH4
• PGL
• CBT1
• CWS3
• PGL1
• QPs3
• SDH4
• cybS
• CII-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
histone modification site profile	0.93
kinase perturbation	0.93
cellular component	0.9
phenotype	0.81

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Succinate Dehydrogenase [Ubiquinone] Cytochrome B Small Subunit, Mitochondrial

DTO Classes

Protein / Transporter / Succinate Dehydrogenase [Ubiquinone] Cytochrome B Small Subunit, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 727.14   (req: < 5)

Gene RIFs: 119   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 727.14   (req: >= 5)

Gene RIFs: 119   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0