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Tbio
CDK2AP1
Cyclin-dependent kinase 2-associated protein 1

Protein Summary
Description
specific inhibitor of the cell-cycle kinase CDK2. The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261692
  • ENSP00000261692
  • ENSG00000111328
  • ENST00000535979
  • ENSP00000442565
  • ENST00000538446
  • ENSP00000442502
  • ENST00000542174
  • ENSP00000440729
  • ENST00000544658
  • ENSP00000438561
  • ENST00000618072
  • ENSP00000479982

Symbol
  • CDKAP1
  • DOC1
  • DOC1
  • ST19
  • DORC1
  • doc-1
  • p12DOC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.97
transcription factor perturbation
0.74
PubMedID
0.73
interacting protein
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.22   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.22   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0