Tbio NRG2 Pro-neuregulin-2, membrane-bound isoform

Protein Summary

Description

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor. This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• O14511
• Pro-NRG2

Gene Name

• NRG2

Ensembl ID

• ENST00000289409
• ENSP00000289409
• ENSG00000158458
• ENST00000289422
• ENSP00000289422
• ENST00000340391
• ENSP00000342660
• ENST00000358522
• ENSP00000351323
• ENST00000361474
• ENSP00000354910
• ENST00000378238
• ENSP00000367483

Symbol

• NTAK
• DON1
• HRG2
• NTAK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
trait	0.75
tissue sample	0.69
microRNA	0.65
cell type or tissue	0.62

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Pro-neuregulin-2, Membrane-bound Isoform

DTO Classes

Protein / Signaling / Growth Factor / Pro-neuregulin-2, Membrane-bound Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.61   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.61   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0