Property Summary

NCBI Gene PubMed Count 15
Grant Count 5
R01 Count 5
Funding $516,868.67
PubMed Score 108.97
PubTator Score 47.99

Knowledge Summary

Patent

No data available

Expression

Gene RIF (6)

PMID Text
24412565 Results demonstrate that truncation of the evolutionarily conserved N-terminal residues of FBP2 results in a loss of its mitochondria-protective functions.
24063558 FBP2 does negatively regulate cell growth, and reduced expression of FBP2 may contribute to carcinogenesis for gastric cancer.
20800603 Observational study of gene-disease association. (HuGE Navigator)
18214967 The existence of highly AMP-sensitive muscle-like FBPase, activity of which is regulated by metabolite-dependent interaction with aldolase enables the precise regulation of muscle energy expenditures.
16213487 The key role in strong AMP binding to muscle isozyme play K20, T177 and Q179.
9282826 HIV-1 Matrix activates fructose 1,6-bisphosphatase gene expression by induction of a 1alpha-hydroxylase activity

AA Sequence

MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLYGIAGSVNVTGDE      1 - 70
VKKLDVLSNSLVINMVQSSYSTCVLVSEENKDAIITAKEKRGKYVVCFDPLDGSSNIDCLASIGTIFAIY     71 - 140
RKTSEDEPSEKDALQCGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIY    141 - 210
SLNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFLYPANQKSPKGKLRLLY    211 - 280
ECNPVAYIIEQAGGLATTGTQPVLDVKPEAIHQRVPLILGSPEDVQEYLTCVQKNQAGS               281 - 339
//

Text Mined References (20)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
24412565 2014 Changes in quaternary structure of muscle fructose-1,6-bisphosphatase regulate affinity of the enzyme to mitochondria.
24086250 2013 Crystal structures of human muscle fructose-1,6-bisphosphatase: novel quaternary states, enhanced AMP affinity, and allosteric signal transmission pathway.
24063558 2013 Decreased fructose-1,6-bisphosphatase-2 expression promotes glycolysis and growth in gastric cancer cells.
22120740 2011 Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase.
20800603 2010 Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
19893584 2010 Identification of 15 loci influencing height in a Korean population.
19626708 2009 Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence.
19056867 2009 Large-scale proteomics and phosphoproteomics of urinary exosomes.
18214967 2008 Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase.
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