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  5. Lipid kinase
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  7. Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Tchem Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

Ligand Count 7
NCBI Gene PubMed Count 46
PubMed Score 34.66
PubTator Score 28.56

Knowledge Summary

Patent (2,372)

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Neoplasm Metastasis 168 0.0 0.0
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.0
Disease Target Count Z-score Confidence
ulcerative colitis 1819 0.0 3.0
Disease Target Count Z-score Confidence
Centronuclear myopathy 27 3.071 1.5

Expression

  Differential Expression (10)

Disease log2 FC p
astrocytic glioma -1.100 1.5e-02
Chronic Lymphocytic Leukemia -1.825 1.6e-10
ependymoma -1.300 2.5e-02
intraductal papillary-mucinous adenoma (... 1.800 1.2e-04
intraductal papillary-mucinous carcinoma... 1.800 5.1e-03
intraductal papillary-mucinous neoplasm ... 2.000 1.5e-03
lung cancer -1.600 3.4e-02
malignant mesothelioma -1.900 2.5e-07
pituitary cancer 1.400 3.3e-04
Waldenstrons macroglobulinemia -1.378 1.1e-05

Synonym

Accession O00750 O95666 Q5SW99 PI3K-C2-beta
Symbols C2-PI3K

Gene

PIK3C2B

PANTHER Protein Class (2)

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 Collection (2)

 UniProt Keyword (12)

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 GO Function (5)

 GO Component (7)

 GO Process (6)

 Compartment GO Term (34)

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 HCA RNA Cell Line (56)

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Pathway (26)

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Ligand (7)

Structure of CHEMBL2165017

CHEMBL2165017
pIC50 7.54

Structure of CHEMBL573339

CHEMBL573339
pIC50 7.59

Structure of CHEMBL1765602

CHEMBL1765602
pIC50 7.61

Structure of CHEMBL538346

CHEMBL538346
pIC50 8.00

Structure of CHEMBL230011

CHEMBL230011
pKd 8.14

Structure of PI-103

PI-103
pIC50 8.00

Structure of torin 2

torin 2
pIC50 7.61

Gene RIF (57)

AA Sequence 

MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGVDFYSK      1 - 70
PAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSS     71 - 140
SPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEE    141 - 210
EEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTM    211 - 280
PPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGS    281 - 350
DIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVD    351 - 420
VGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHL    421 - 490
QERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPP    491 - 560
CPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARS    561 - 630
LAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLP    631 - 700
RETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSA    701 - 770
PNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLW    771 - 840
EKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSL    841 - 910
SDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLC    911 - 980
CCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIV    981 - 1050
PRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCF   1051 - 1120
STGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYV   1121 - 1190
LGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDL   1191 - 1260
CCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATK   1261 - 1330
LNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEAT   1331 - 1400
YIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLV   1401 - 1470
YTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDP   1471 - 1540
YVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIR   1541 - 1610
LRELDLAQEKTGWFALGSRSHGTL                                                 1611 - 1634
//

Text Mined References (47)

PMID Year Title