| Tchem | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta |
Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 45 |
| Grant Count | 11 |
| R01 Count | 5 |
| Funding | $1,709,540 |
| PubMed Score | 30.60 |
| PubTator Score | 28.56 |
| Disease | log2 FC | p |
|---|---|---|
| Waldenstrons macroglobulinemia | -1.378 | 0.000 |
| Chronic Lymphocytic Leukemia | -1.825 | 0.000 |
| malignant mesothelioma | -1.900 | 0.000 |
| astrocytic glioma | -1.100 | 0.015 |
| ependymoma | -1.300 | 0.025 |
| intraductal papillary-mucinous adenoma (... | 1.800 | 0.000 |
| intraductal papillary-mucinous carcinoma... | 1.800 | 0.005 |
| intraductal papillary-mucinous neoplasm ... | 2.000 | 0.001 |
| lung cancer | -1.600 | 0.034 |
| pituitary cancer | 1.400 | 0.000 |
CHEMBL2165017
pIC50 7.54
CHEMBL573339
pIC50 7.59
CHEMBL1765602
pIC50 7.61
CHEMBL538346
pIC50 8.00
CHEMBL230011
pKd 8.14
| PMID | Text |
|---|---|
| 25622909 | PI3KC2B-silencing inhibits early stages of neuroblastoa tumorigenic growth. |
| 24073214 | HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells |
| 23320105 | Class II enzyme PI3K-C2beta and the class IB isozyme p110gamma mainly regulate the S1P- and high density lipoprotein (HDL)-dependent endothelial cell (EC) migration and PI3K-C2alpha primarily controls EC survival |
| 23301033 | HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells |
| 23251686 | HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells |
| 23215766 | HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells |
| 23028960 | Data suggest a novel role for nucleotide-free Ras in cell signaling in which PI3KC2beta stabilizes nucleotide-free Ras and that interaction of Ras and PI3KC2beta mutually inhibit one another. |
| 22825724 | The results of this study showed that strong association between PIK3C2B gene alternation and high-grade oligodendroglial tumors. |
| 22128329 | These findings provide a unique mechanism for regulating class II PI3Ks, and identify TRIM27 as a previously undescribed negative regulator of CD4 T cells. |
| 21986133 | Overexpression of PIK3C2B is associated with esophageal squamous cell carcinoma. |
| More... |
MSSTQGNGEHWKSLESVGISRKELAMAEALQMEYDALSRLRHDKEENRAKQNADPSLISWDEPGVDFYSK 1 - 70 PAGRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGGVSS 71 - 140 SPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSLVEQLPGKLLEHRILEE 141 - 210 EEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPLDFSKDTSGKPVARSKTM 211 - 280 PPQVPPRTYASRYGNRKNATPGKNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCHMLDILRSGS 281 - 350 DIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVLCDRLQEALTFTCNCSSTVDLLIYQTLCYTHDDLRNVD 351 - 420 VGDFVLKPCGLEEFLQNKHALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDDQSPSTLNYLVHL 421 - 490 QERPVKQTISRQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPP 491 - 560 CPSRMQPKIQKDPSVLAVRENREKVVEALTAAILDLVELYCNTFNADFQTAVPGSRKHDLVQEACHFARS 561 - 630 LAFTVYATHRIPIIWATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQVNRLP 631 - 700 RETLLCATLYALPIPPPGSSSEANKQRRVPEALGWVTTPLFNFRQVLTCGRKLLGLWPATQENPSARWSA 701 - 770 PNFHQPDSVILQIDFPTSAFDIKFTSPPGDKFSPRYEFGSLREEDQRKLKDIMQKESLYWLTDADKKRLW 771 - 840 EKRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVRRMAVQWIGSL 841 - 910 SDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQFSIRYQYLLAALLC 911 - 980 CCGKGLREEFNRQCWLVNALAKLAQQVREAAPSARQGILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIV 981 - 1050 PRDCSYFNSNAVPLKLSFQNVDPLGENIRVIFKCGDDLRQDMLTLQMIRIMSKIWVQEGLDMRMVIFRCF 1051 - 1120 STGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGEDEYEKAVENFIYSCAGCCVATYV 1121 - 1190 LGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDL 1191 - 1260 CCQAYNLIRKHTHLFLNLLGLMLSCGIPELSDLEDLKYVYDALRPQDTEANATTYFTRLIESSLGSVATK 1261 - 1330 LNFFIHNLAQMKFTGSDDRLTLSFASRTHTLKSSGRISDVFLCRHEKIFHPNKGYIYVVKVMRENTHEAT 1331 - 1400 YIQRTFEEFQELHNKLRLLFPSSHLPSFPSRFVIGRSRGEAVAERRREELNGYIWHLIHAPPEVAECDLV 1401 - 1470 YTFFHPLPRDEKAMGTSPAPKSSDGTWARPVGKVGGEVKLSISYKNNKLFIMVMHIRGLQLLQDGNDPDP 1471 - 1540 YVKIYLLPDPQKTTKRKTKVARKTCNPTYNEMLVYDGIPKGDLQQRELQLSVLSEQGFWENVLLGEVNIR 1541 - 1610 LRELDLAQEKTGWFALGSRSHGTL 1611 - 1634 //
| PMID | Year | Title |
|---|---|---|
| 25622909 | 2015 | Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2?) isoform contributes to neuroblastoma tumorigenesis. |
| 24658140 | 2014 | The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. |
| 23535733 | 2013 | Genome-wide association studies identify four ER negative-specific breast cancer risk loci. |
| 23535732 | 2013 | Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. |
| 23320105 | 2013 | Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. |
| 23028960 | 2012 | A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2?) regulation. |
| 22825724 | 2012 | Identification of a novel population in high-grade oligodendroglial tumors not deleted on 1p/19q using array CGH. |
| 22128329 | 2011 | Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2?. |
| 21986133 | 2011 | Phosphatidylinositol 3-kinase-C2? inhibits cisplatin-mediated apoptosis via the Akt pathway in oesophageal squamous cell carcinoma. |
| 21706016 | 2011 | Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor. |
| More... |
