| Tchem | Cocaine esterase |
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Comments
Property Summary
| Ligand Count | 91 |
| NCBI Gene PubMed Count | 62 |
| PubMed Score | 271.08 |
| PubTator Score | 318.29 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cocaine-Related Disorders | 92 | 0.0 | 0.0 |
| Drug-Related Side Effects and Adverse Reactions | 62 | 0.0 | 0.0 |
| Liver Cirrhosis, Experimental | 769 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Adverse reaction to drug | 61 |
| Disease | Target Count | P-value |
|---|---|---|
| acute quadriplegic myopathy | 1158 | 4.4e-06 |
| ovarian cancer | 8520 | 1.5e-05 |
| ulcerative colitis | 1819 | 1.8e-05 |
| Becker muscular dystrophy | 191 | 5.0e-05 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.4e-03 |
| colon cancer | 1478 | 7.5e-03 |
| osteosarcoma | 7950 | 8.5e-03 |
| active Crohn's disease | 922 | 1.7e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 4.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -1.014 | 1.7e-02 |
| acute quadriplegic myopathy | 1.461 | 4.4e-06 |
| Becker muscular dystrophy | 1.065 | 5.0e-05 |
| colon cancer | -1.700 | 7.5e-03 |
| intraductal papillary-mucinous neoplasm ... | 2.300 | 2.4e-03 |
| osteosarcoma | -1.580 | 8.5e-03 |
| ovarian cancer | 1.300 | 1.5e-05 |
| pancreatic ductal adenocarcinoma liver m... | -1.235 | 4.0e-02 |
| ulcerative colitis | -1.700 | 1.8e-05 |
CHEMBL117447
pKi 6.02
CHEMBL364729
pKi 6.06
CHEMBL242288
pKi 6.08
CHEMBL2151605
pIC50 6.18
CHEMBL396977
pKi 6.19
CHEMBL190672
pKi 6.24
CHEMBL242506
pKi 6.26
CHEMBL1812861
pKi 6.31
CHEMBL394807
pKi 6.40
CHEMBL191796
pKi 6.40
CHEMBL244425
pKi 6.41
CHEMBL195713
pKi 6.42
CHEMBL193180
pKi 6.44
CHEMBL365392
pKi 6.45
CHEMBL1812851
pKi 6.48
CHEMBL155396
pIC50 6.51
CHEMBL187460
pKi 6.54
CHEMBL1812852
pKi 6.57
CHEMBL1812857
pKi 6.57
CHEMBL242287
pKi 6.57
MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQVLGSLVHVKGANAGVQTFLGIPFAKPPLGP 1 - 70 LRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNL 71 - 140 PVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQ 141 - 210 NIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVVANLSAC 211 - 280 DQVDSEALVGCLRGKSKEEILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLI 281 - 350 PKVMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPA 351 - 420 LQVAHFQCSRAPVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSRKMMKY 421 - 490 WANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL 491 - 559 //
