Property Summary

NCBI Gene PubMed Count 188
Grant Count 200
R01 Count 125
Funding $17,041,909.17
PubMed Score 298.74
PubTator Score 286.29

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession O00622 O14934 O43775 Q9BZL7
Symbols CCN1
GIG1
IGFBP10

Gene

PANTHER Protein Class (2)

PDB

4D0Z   4D11  

Gene RIF (169)

PMID Text
26923924 we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP-dependent induction of CYR61/CCN1 and miR-296-3p.
26630293 up-regulated in epithelial cells of salivary glands of primary Sjogren's syndrome patients
26498181 Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer.
26459773 Data show that RNA silencing of CCN family member 1 protein (CCN1) inhibits umbilical vein endothelial cell (HUVEC) proliferation under hypoxic conditions by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling.
26424659 Report shows evidence that CCN1 is O-fucosylated at Threonine 242 and that O-fucosylation of CCN1 regulates its secretion.
26203933 The expression of CYR61,that regulates fibroblast-like synoviocites proliferation and T helper 17 cell differentiation,appears to be crucial in mediating joint inflammation in Rheumatoid arthritis.
26201842 It promotes cell growth and angiogenesis in cancers through its interaction with several integrins and proved to be an independent prognostic factor for patient survival.
26028023 CCN1 is an injury response protein that functions not only to restrict fibrosis in the liver, but also to suppress hepatocarcinogenesis by inhibiting EGFR-dependent hepatocyte compensatory proliferation
25980494 c-Src regulates secreted proteins, including the exosomal Cyr61, which are involved in modulating the metastatic potential of triple negative breast cancer cells.
25974135 SYK is downstream of CYR61 and contributes to CYR61-mediated mitoxantrone resistance. The CYR61-SYK pathway represents a potential target for reducing stroma-induced chemoresistance
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AA Sequence

MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPC      1 - 70
DHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSL     71 - 140
PNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRL    141 - 210
PVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSL    211 - 280
KKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMI    281 - 350
QSCKCNYNCPHANEAAFPFYRLFNDIHKFRD                                           351 - 381
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Text Mined References (189)

PMID Year Title
26923924 2016 Neurofibromatosis 2 (NF2) controls the invasiveness of glioblastoma through YAP-dependent expression of CYR61/CCN1 and miR-296-3p.
26630293 2016 Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression.
26498181 2015 Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
26459773 2015 CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.
26424659 2015 O-Fucosylation of CCN1 is required for its secretion.
26203933 One year in review: the pathogenesis of rheumatoid arthritis.
26201842 2015 Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma.
26091039 2015 A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
26028023 2016 The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.
25980494 2015 Cyr61 as mediator of Src signaling in triple negative breast cancer cells.
More...