Property Summary

NCBI Gene PubMed Count 188
PubMed Score 298.74
PubTator Score 286.29

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count P-value
lung carcinoma 2844 7.37503356283492E-20
breast carcinoma 1614 1.88892941364616E-16
periodontitis 269 1.59970579361988E-14
psoriasis 6685 1.67937751472211E-12
juvenile dermatomyositis 1189 1.11337969944021E-8
lung cancer 4473 1.50447014323169E-6
inflammatory breast cancer 404 4.02023619943312E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 6.07123407873916E-6
ulcerative colitis 2087 7.11138179270584E-6
ovarian cancer 8492 7.82992939813022E-6
non-small cell lung cancer 2798 1.41967802271878E-5
acute quadriplegic myopathy 1157 1.47583196321975E-5
posterior fossa group A ependymoma 1511 4.63436930273535E-5
Amyotrophic Lateral Sclerosis 432 1.83456357452814E-4
primary pancreatic ductal adenocarcinoma 1271 3.52249807035396E-4
pancreatic cancer 2300 6.55933093557329E-4
interstitial cystitis 2299 6.61470061248401E-4
glioblastoma 5572 7.20358506654262E-4
autosomal dominant Emery-Dreifuss muscular dystrophy 499 9.00293839997208E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 9.86909725908502E-4
pituitary cancer 1972 0.0010923068401118
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00125493694521754
fascioscapulohumeral muscular dystrophy 100 0.0023044243379009
adrenocortical carcinoma 1427 0.00273817951681084
atypical teratoid / rhabdoid tumor 4369 0.00285176331752006
nephrosclerosis 329 0.00456529308762266
lung adenocarcinoma 2714 0.00475358085238055
cystic fibrosis 1670 0.00806776562570427
group 4 medulloblastoma 1875 0.00998549557397323
limb girdle muscular dystrophy 2I 56 0.0100077006200505
gastric carcinoma 832 0.0189419586526486
subependymal giant cell astrocytoma 2287 0.0303474768196024
non primary Sjogren syndrome sicca 840 0.0348800829820405
spina bifida 1064 0.0394211265537293
sarcoidosis 368 0.0442066412081252
diabetes mellitus 1663 0.0468098074989687
osteosarcoma 7933 0.049022705014631
Disease Target Count Z-score Confidence
Cancer 2346 4.313 2.2

Expression

Synonym

Accession O00622 O14934 O43775 Q9BZL7
Symbols CCN1
GIG1
IGFBP10

Gene

PANTHER Protein Class (2)

PDB

4D0Z   4D11  

  Ortholog (11)

Gene RIF (169)

PMID Text
26923924 we demonstrate that NF2 negatively controls the invasiveness of Glioblastoma multiforme through YAP-dependent induction of CYR61/CCN1 and miR-296-3p.
26630293 up-regulated in epithelial cells of salivary glands of primary Sjogren's syndrome patients
26498181 Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer.
26459773 Data show that RNA silencing of CCN family member 1 protein (CCN1) inhibits umbilical vein endothelial cell (HUVEC) proliferation under hypoxic conditions by inhibiting phosphoinositide 3-kinase (PI3K)/AKT protein signaling.
26424659 Report shows evidence that CCN1 is O-fucosylated at Threonine 242 and that O-fucosylation of CCN1 regulates its secretion.
26203933 The expression of CYR61,that regulates fibroblast-like synoviocites proliferation and T helper 17 cell differentiation,appears to be crucial in mediating joint inflammation in Rheumatoid arthritis.
26201842 It promotes cell growth and angiogenesis in cancers through its interaction with several integrins and proved to be an independent prognostic factor for patient survival.
26028023 CCN1 is an injury response protein that functions not only to restrict fibrosis in the liver, but also to suppress hepatocarcinogenesis by inhibiting EGFR-dependent hepatocyte compensatory proliferation
25980494 c-Src regulates secreted proteins, including the exosomal Cyr61, which are involved in modulating the metastatic potential of triple negative breast cancer cells.
25974135 SYK is downstream of CYR61 and contributes to CYR61-mediated mitoxantrone resistance. The CYR61-SYK pathway represents a potential target for reducing stroma-induced chemoresistance
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AA Sequence

MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPC      1 - 70
DHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSL     71 - 140
PNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRL    141 - 210
PVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSL    211 - 280
KKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMI    281 - 350
QSCKCNYNCPHANEAAFPFYRLFNDIHKFRD                                           351 - 381
//

Text Mined References (189)

PMID Year Title
26923924 2016 Neurofibromatosis 2 (NF2) controls the invasiveness of glioblastoma through YAP-dependent expression of CYR61/CCN1 and miR-296-3p.
26630293 2016 Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression.
26498181 2015 Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
26459773 2015 CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy.
26424659 2015 O-Fucosylation of CCN1 is required for its secretion.
26203933 One year in review: the pathogenesis of rheumatoid arthritis.
26201842 2015 Evaluation of extracellular matrix protein CCN1 as a prognostic factor for glioblastoma.
26091039 2015 A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
26028023 2016 The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation.
25980494 2015 Cyr61 as mediator of Src signaling in triple negative breast cancer cells.
More...