Property Summary

NCBI Gene PubMed Count 82
PubMed Score 209.86
PubTator Score 245.48

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Degenerative polyarthritis 93
Disease Target Count P-value
lung carcinoma 2844 1.18092652226124E-20
ovarian cancer 8492 1.41661932445182E-7
Duchenne muscular dystrophy 602 5.68739835903228E-7
lung cancer 4473 5.299865051266E-5
glioblastoma 5572 1.59457538744501E-4
dermatomyositis 967 6.85816511889464E-4
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00246832128668135
medulloblastoma, large-cell 6234 0.00644542084875574
diabetes mellitus 1663 0.00654169144994668
subependymal giant cell astrocytoma 2287 0.0180232930471084
astrocytoma 1493 0.0200330079871064
Waldenstrons macroglobulinemia 765 0.0293344197536219
Disease Target Count Z-score Confidence
Pontiac fever 3 4.094 2.0
Disuse amblyopia 3 3.704 1.9
Asthenopia 11 3.573 1.8


  Differential Expression (12)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.460 0.029
astrocytoma 1.200 0.020
glioblastoma 1.500 0.000
medulloblastoma, large-cell -1.100 0.006
Duchenne muscular dystrophy 1.230 0.000
autosomal dominant Emery-Dreifuss muscul... 1.243 0.002
lung cancer -1.400 0.000
diabetes mellitus -1.100 0.007
subependymal giant cell astrocytoma 1.894 0.018
lung carcinoma -1.300 0.000
ovarian cancer -2.100 0.000
dermatomyositis 1.500 0.001


Accession O00560 B2R5Q7 B4DUH3 B7ZLN2 O00173 O43391 Q14CP2
Symbols ST1



4Z33   1N99   1NTE   1OBX   1OBY   1OBZ   1R6J   1V1T   1W9E   1W9O   1W9Q   1YBO  

  Ortholog (12)

Gene RIF (43)

26787460 Data suggest that syntenin/SDCBP PDZ domains 1 and 2 recognize a broad range of peptide ligands with preferences for nectin-1, hydrophobic amino acid motifs, and cryptic internal ligands/peptide fragments.
26561205 Data show that patients with high MDA-9/Syntenin and high Slug expressions were associated with poor overall survival compared to those with low expression in lung adenocarcinomas.
26093898 To predict mda-9's association with extracellular matrix organization.
25893292 these findings demonstrate that syntenin may act as an important positive regulator of TGF-b signaling by regulating caveolin-1-mediated internalization of TbRI; thus, providing a novel function for syntenin that is linked to cancer progression.
25480418 MDA-9, co-expressed with GRP78, as a melanoma protein associated with lymph node metastasis. Investigating how MDA-9 and GRP78 interact to contribute to melanoma metastasis and disease progression could reveal new potential avenues of targeted therapy
24662291 ALCAM stably interacts with actin by binding to syntenin-1 and ezrin.
24637612 Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2.
24305713 High MDA-9 expresison is associated with glioma.
23873690 Our findings indicate that MDA-9/Syntenin might provide an attractive target for developing detection, monitoring, and therapeutic strategies for managing Urothelial cell carcinoma .
23533663 Results suggested that SDCBP played an important role in tumor growth of ER-negative breast cancers.

AA Sequence

RMAPSIMKSLMDHTIPEV                                                        281 - 298

Text Mined References (93)

PMID Year Title
27386966 2016 Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
26787460 2016 Proteomic peptide phage display uncovers novel interactions of the PDZ1-2 supramodule of syntenin.
26561205 2016 MDA-9/Syntenin-Slug transcriptional complex promote epithelial-mesenchymal transition and invasion/metastasis in lung adenocarcinoma.
26539120 2015 Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells.
26291527 2016 MDA-9/Syntenin Control.
26093898 2015 Examination of Epigenetic and other Molecular Factors Associated with mda-9/Syntenin Dysregulation in Cancer Through Integrated Analyses of Public Genomic Datasets.
26032692 2015 Syntenin and syndecan in the biogenesis of exosomes.
25893292 2016 Syntenin regulates TGF-?1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-? type I receptor internalization.
25480418 2015 MDA-9 and GRP78 as potential diagnostic biomarkers for early detection of melanoma metastasis.