Tchem STK25 Serine/threonine-protein kinase 25

Protein Summary

Description

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• O00506
• A8K6Z3
• A8K7D2
• B7Z9K1
• Q15522
• Q5BJF1

Gene Name

• STK25

Ensembl ID

• ENST00000316586
• ENSP00000325748
• ENSG00000115694
• ENST00000401869
• ENSP00000385687
• ENST00000403346
• ENSP00000384162
• ENST00000405585
• ENSP00000385541
• ENST00000405883
• ENSP00000384444
• ENST00000535007
• ENSP00000446008
• ENST00000543554
• ENSP00000444886

Symbol

• SOK1
• YSK1
• SOK1
• YSK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
disease perturbation	0.87
transcription factor binding site profile	0.87
biological process	0.79
gene perturbation	0.76

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Ysk Subfamily / Serine/threonine-protein Kinase 25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.25   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 241   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.25   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1