Tbio SLC17A3 Sodium-dependent phosphate transport protein 4

Protein Summary

Description

Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport. The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• O00476
• B7WNJ5
• B7Z511
• Q8WWC7
• Q9H533

Gene Name

• SLC17A3

Ensembl ID

• ENST00000360657
• ENSP00000353873
• ENSG00000124564
• ENST00000361703
• ENSP00000355307
• ENST00000397060
• ENSP00000380250

Symbol

• NPT4
• NPT4
• GOUT4
• UAQTL4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
co-expressed gene	0.91
phenotype	0.64
disease	0.6
cell type or tissue	0.56

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Sodium-dependent Phosphate Transport Protein 4

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc17 Phosphate And Organic Anion Transporter Family / Type I Sodium-phosphate Co-transporters / Sodium-dependent Phosphate Transport Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.58   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0