LST1
Leukocyte-specific transcript 1 protein
Protein Summary
Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000303757
- ENSP00000303649
- ENSG00000204482
- ENST00000339530
- ENSP00000339201
- ENST00000376086
- ENSP00000365254
- ENST00000376089
- ENSP00000365257
- ENST00000376092
- ENSP00000365260
- ENST00000376093
- ENSP00000365261
- ENST00000376096
- ENSP00000365264
- ENST00000376110
- ENSP00000365278
- ENST00000383480
- ENSP00000372972
- ENSG00000206433
- ENST00000383482
- ENSP00000372974
- ENST00000383484
- ENSP00000372976
- ENST00000383486
- ENSP00000372978
- ENST00000400250
- ENSP00000383109
- ENST00000400257
- ENSP00000383116
- ENST00000400262
- ENSP00000383121
- ENST00000400263
- ENSP00000383122
- ENST00000400264
- ENSP00000383123
- ENST00000400265
- ENSP00000383124
- ENST00000411490
- ENSP00000395409
- ENSG00000235915
- ENST00000412041
- ENSP00000399411
- ENSG00000231048
- ENST00000412623
- ENSP00000409229
- ENSG00000226182
- ENST00000413426
- ENSP00000408876
- ENST00000414266
- ENSP00000402707
- ENSG00000223465
- ENST00000415419
- ENSP00000415143
- ENST00000415490
- ENSP00000390658
- ENSG00000234514
- ENST00000415781
- ENSP00000401655
- ENST00000417428
- ENSP00000394614
- ENST00000418507
- ENSP00000405900
- ENST00000420157
- ENSP00000398700
- ENST00000420333
- ENSP00000411547
- ENSG00000230791
- ENST00000420676
- ENSP00000414246
- ENST00000420785
- ENSP00000393345
- ENST00000420797
- ENSP00000390587
- ENST00000422035
- ENSP00000396431
- ENST00000422533
- ENSP00000412627
- ENST00000423107
- ENSP00000406438
- ENST00000423871
- ENSP00000400069
- ENST00000425760
- ENSP00000409698
- ENST00000426938
- ENSP00000404051
- ENST00000427186
- ENSP00000399439
- ENST00000427507
- ENSP00000416283
- ENST00000428227
- ENSP00000413526
- ENST00000428405
- ENSP00000391963
- ENST00000428898
- ENSP00000389694
- ENST00000429874
- ENSP00000387560
- ENST00000429910
- ENSP00000399063
- ENST00000430632
- ENSP00000392949
- ENST00000430680
- ENSP00000398918
- ENST00000430997
- ENSP00000389795
- ENST00000432009
- ENSP00000409433
- ENST00000432164
- ENSP00000394834
- ENST00000433004
- ENSP00000390430
- ENST00000433305
- ENSP00000407417
- ENST00000433676
- ENSP00000411866
- ENST00000434314
- ENSP00000414173
- ENST00000436037
- ENSP00000398685
- ENST00000436185
- ENSP00000396579
- ENST00000437137
- ENSP00000412276
- ENST00000437436
- ENSP00000394891
- ENST00000437812
- ENSP00000396179
- ENST00000438075
- ENSP00000391929
- ENST00000438335
- ENSP00000403097
- ENST00000438349
- ENSP00000391057
- ENST00000438381
- ENSP00000393282
- ENST00000440242
- ENSP00000394815
- ENST00000440253
- ENSP00000396235
- ENST00000440323
- ENSP00000414744
- ENST00000440328
- ENSP00000401516
- ENST00000442052
- ENSP00000399474
- ENST00000443340
- ENSP00000396533
- ENST00000443655
- ENSP00000411961
- ENST00000443741
- ENSP00000388956
- ENST00000446239
- ENSP00000402873
- ENST00000447141
- ENSP00000397826
- ENST00000447391
- ENSP00000411087
- ENST00000448236
- ENSP00000406455
- ENST00000448441
- ENSP00000409008
- ENST00000449236
- ENSP00000391420
- ENST00000449273
- ENSP00000415623
- ENST00000450291
- ENSP00000404500
- ENST00000450425
- ENSP00000415168
- ENST00000451641
- ENSP00000406625
- ENST00000451922
- ENSP00000401567
- ENST00000452169
- ENSP00000416808
- ENST00000453995
- ENSP00000409163
- ENST00000454168
- ENSP00000396004
- ENST00000455003
- ENSP00000396181
- ENST00000455052
- ENSP00000398228
- ENST00000455426
- ENSP00000398780
- ENST00000455493
- ENSP00000401650
- ENST00000455655
- ENSP00000415526
- ENST00000455901
- ENSP00000396378
- ENST00000457549
- ENSP00000390885
- ENST00000458456
- ENSP00000405920
- B144
- B144
- LST-1
- D6S49E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cellular component | 0.72 | ||
tissue sample | 0.7 | ||
disease | 0.67 | ||
phenotype | 0.66 | ||
co-expressed gene | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.42 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 161 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.42 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 161 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0