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Tchem
PLK4
Serine/threonine-protein kinase PLK4

Protein Summary
Description
Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270861
  • ENSP00000270861
  • ENSG00000142731
  • ENST00000513090
  • ENSP00000427554
  • ENST00000514379
  • ENSP00000423582

Symbol
  • SAK
  • STK18
  • SAK
  • STK18
  • MCCRP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
gene perturbation
0.89
histone modification site profile
0.89
transcription factor perturbation
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.87   (req: < 5)
Gene RIFs: 113   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 590.87   (req: >= 5)
Gene RIFs: 113   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 121
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3