Property Summary

NCBI Gene PubMed Count 10
Grant Count 66
R01 Count 30
Funding $21,837,258.72
PubMed Score 85.11
PubTator Score 37.03

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (8)

Disease log2 FC p
Multiple myeloma 1.479 0.003
glioblastoma 1.200 0.004
tuberculosis and treatment for 6 months 1.100 0.002
lung cancer 1.100 0.001
Alzheimer's disease -1.100 0.024
Pick disease -1.400 0.000
ovarian cancer 2.600 0.000
dermatomyositis 1.400 0.002

Synonym

Accession O00442 Q5VVL5 Q5VVL6 Q96E99 RNA cyclase
Symbols RPC
RTC1
RTCD1

Gene

Gene RIF (1)

PMID Text
19690099 Rtc1 forms a stable binary complex with a 3'-phosphate terminated RNA, but not with an identical 3'-OH terminated RNA

AA Sequence

MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIRDLCDGQLEGA      1 - 70
EIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELHLKGGTNAEMAPQIDYTVMVF     71 - 140
KPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNPINLTERGCVTKIYGRAFVAGVLPFKVAKDM    141 - 210
AAAAVRCIRKEIRDLYVNIQPVQEPKDQAFGNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEM    211 - 280
LLANLRHGGTVDEYLQDQLIVFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKD    281 - 350
TYIIECQGIGMTNPNL                                                          351 - 366
//

Text Mined References (12)

PMID Year Title
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
21269460 2011 Initial characterization of the human central proteome.
19690099 2009 Structure-activity relationships in human RNA 3'-phosphate cyclase.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17353931 2007 Large-scale mapping of human protein-protein interactions by mass spectrometry.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9184239 1997 The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.
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