Tbio SLC28A1 Sodium/nucleoside cotransporter 1

Protein Summary

Description

Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.

Uniprot Accession IDs

• O00337
• A0AV42
• A8K7I2
• O00335
• O00336
• Q5U5S6
• Q5U648
• Q9UEZ9

Gene Name

• SLC28A1

Ensembl ID

• ENST00000286749
• ENSP00000286749
• ENSG00000156222
• ENST00000338602
• ENSP00000341629
• ENST00000394573
• ENSP00000378074

Symbol

• CNT1
• CNT1
• HCNT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
protein domain	0.85
microRNA	0.59
cell line	0.56
cell type or tissue	0.55

Protein Classes

PANTHER Classes

Protein / Transporter / Sodium/nucleoside Cotransporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc28 And Slc29 Families Of Nucleoside Transporters / Slc28 Family / Sodium/nucleoside Cotransporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.05   (req: < 5)

Gene RIFs: 33   (req: <= 3)

Antibodies: 59   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.05   (req: >= 5)

Gene RIFs: 33   (req: > 3)

Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0