Property Summary

NCBI Gene PubMed Count 66
Grant Count 62
R01 Count 42
Funding $6,616,571.49
PubMed Score 55.68
PubTator Score 101.21

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (24)

Disease log2 FC p
Rheumatoid Arthritis 1.800 0.002
malignant mesothelioma -2.400 0.000
psoriasis -1.700 0.000
astrocytoma 1.200 0.000
glioblastoma 2.400 0.000
oligodendroglioma 1.200 0.000
osteosarcoma 1.428 0.002
atypical teratoid / rhabdoid tumor 1.600 0.000
medulloblastoma, large-cell 1.700 0.000
primitive neuroectodermal tumor 1.800 0.000
adrenocortical carcinoma 1.170 0.005
primary pancreatic ductal adenocarcinoma 1.391 0.002
diabetes mellitus 1.200 0.003
pediatric high grade glioma 1.800 0.000
group 3 medulloblastoma 1.500 0.003
pilocytic astrocytoma 2.500 0.000
aldosterone-producing adenoma -1.214 0.006
lung carcinoma -1.500 0.000
spina bifida 1.385 0.040
gastric carcinoma 1.300 0.010
ovarian cancer 1.500 0.000
Down syndrome 1.100 0.001
pancreatic cancer 1.200 0.007
facioscapulohumeral dystrophy -1.300 0.040

Synonym

Accession O00291 B4E3I7 E7ES17 O00328 Q2TB58 Q8TDL4 V5LU97 HIP-1
Symbols SHON
HIP-I
ILWEQ
SHONbeta
SHONgamma

Gene

PDB

2NO2   2QA7   3I00  

Gene RIF (28)

PMID Text
26595459 Huntingtin-interacting protein-1 (HIP1) is known to play a role in tumorigenesis. metastasis. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201412-2226OC#.V8DF69LrtNs
26437767 HIP1 deletion is not involved in Williams-Beuren syndrome.
25496667 Genome-wide shRNA screening identifies HIP1, which is required for HIV-1 Nef-induced downregulation of CD4 in HeLa CD4+ cells
25082541 SHON plays an important role in EMT and contributes to breast cancer progression.
24518094 HIP1-ALK, a novel fusion protein is associated with lung adenocarcinoma.
24496003 HIP1-ALK-rearranged tumor is sensitive to treatment with crizotinib, implicating HIP1-ALKas an oncogenic driver of lung tumorigenesis
24296488 SHON is a novel human oncogene with predictive utility in ER(+) breast cancer, perhaps offering a simple biomarker to predict the therapeutic efficacy of antiestrogen therapy in patients with breast cancer.
23836884 Identified a four-tyrosine "HIP1 phosphorylation motif" in the N-terminal region of HIP1 that is required for phosphorylation mediated by both EGFR and PDGFbetaR but not by the oncoproteins HIP1/PDGFbetaR (H/P), and TEL/PDGFbetaR (T/P).
22913984 Three neuronal proteins (Huntingtin interacting protein 1, neurofascin, and olfactomedin-like 2a) are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation.
22835334 flexibility of the HIP1 coiled-coil domain is important for normal function and may lead to new insights into Huntington's disease
More...

AA Sequence

MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHE      1 - 70
KGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCS     71 - 140
IYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSR    141 - 210
SVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQ    211 - 280
YFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDI    281 - 350
FGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQ    351 - 420
HLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNA    421 - 490
EVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSA    491 - 560
QSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKA    561 - 630
AEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTS    631 - 700
DAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPR    701 - 770
GLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVA    771 - 840
SKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEI    841 - 910
AASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQE    911 - 980
MDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE                 981 - 1037
//

Text Mined References (71)

PMID Year Title
26595459 2016 Huntingtin-Interacting Protein-1 Is an Early-Stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated Epithelial-Mesenchymal Transition.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26437767 2016 Epilepsy is a possible feature in Williams-Beuren syndrome patients harboring typical deletions of the 7q11.23 critical region.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
25241761 2014 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
25082541 2015 SHON, a novel secreted protein, regulates epithelial-mesenchymal transition through transforming growth factor-? signaling in human breast cancer cells.
24951543 2014 Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
24518094 2014 HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma.
24496003 2014 HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.
More...