Tbio RFXAP Regulatory factor X-associated protein

Protein Summary

Description

Part of the RFX complex that binds to the X-box of MHC II promoters. Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00287
• B2R9T8
• Q5VZM6
• Q8TC40
• RFX-associated protein

Gene Name

• RFXAP

Ensembl ID

• ENST00000255476
• ENSP00000255476
• ENSG00000133111

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.7
tissue sample	0.67
small molecule perturbation	0.65
histone modification site profile	0.62
transcription factor binding site profile	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.01   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 175   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.01   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0