Tbio GPR31 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

Protein Summary

Description

High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.

Uniprot Accession IDs

• O00270
• B0M0K2
• Q4VBL3
• Q9NQ20
• 12-(S)-HETE receptor

Gene Name

• GPR31

Ensembl ID

• ENST00000366834
• ENSP00000355799
• ENSG00000120436

Symbol

• HETER
• HETER1
• 12-HETER

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.63
tissue sample	0.56
virus perturbation	0.5
cell type or tissue	0.44
pathway	0.43

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / 12-(s)-hydroxy-5,8,10,14-eicosatetraenoic Acid Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 110   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0