Property Summary

NCBI Gene PubMed Count 45
PubMed Score 8.09
PubTator Score 4.09

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count
Contact Dermatitis 80
Disease Target Count P-value
non-small cell lung cancer 2798 2.12341621051702E-18
atypical teratoid / rhabdoid tumor 4369 1.08283736666299E-5
ovarian cancer 8492 1.66335969206574E-5
psoriasis 6685 3.57976661366472E-4
invasive ductal carcinoma 2950 0.00948939675174527
lung cancer 4473 0.00995171353331386
osteosarcoma 7933 0.0122748344561357
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0134247093083346
Multiple myeloma 1328 0.0179549946183932
Parkinson's disease 364 0.0309339003684737

Expression

  Differential Expression (10)

Disease log2 FC p
Multiple myeloma 1.390 0.018
psoriasis 1.300 0.000
osteosarcoma 1.043 0.012
atypical teratoid / rhabdoid tumor -1.200 0.000
pancreatic ductal adenocarcinoma liver m... -1.296 0.013
non-small cell lung cancer 1.038 0.000
lung cancer 1.100 0.010
Parkinson's disease -1.100 0.031
invasive ductal carcinoma 1.200 0.009
ovarian cancer 2.400 0.000

Synonym

Accession O00232 A6NP15 Q53HA2 Q6P053
Symbols p55
Rpn5

Gene

PANTHER Protein Class (1)

PDB

5GJQ   5GJR  

  Ortholog (15)

Gene RIF (25)

PMID Text
18854154 Knockdown of proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (PSMD12) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1
14614829 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
14564014 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
14557625 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
14550573 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
14528301 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
14528300 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
14527406 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
12970355 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
12920286 HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication
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AA Sequence

MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAV      1 - 70
VKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEI     71 - 140
ERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKIN    141 - 210
TKFFQEENTEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILAPFD    211 - 280
NEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRKGSLESPATDVFGSTEEGEKR    281 - 350
WKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKD    351 - 420
PNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ                                      421 - 456
//

Text Mined References (53)

PMID Year Title
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
25772364 2015 SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
25218447 2014 Uncovering global SUMOylation signaling networks in a site-specific manner.
25192599 2015 Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.
25114211 2014 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
21944250 2011 A replication study of genome-wide CNV association for hepatic biomarkers identifies nine genes associated with liver function.
21269460 2011 Initial characterization of the human central proteome.
19946888 2010 Defining the membrane proteome of NK cells.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
More...