Property Summary

NCBI Gene PubMed Count 64
Grant Count 5
R01 Count 3
Funding $1,073,171
PubMed Score 118.91
PubTator Score 110.36

Knowledge Summary


No data available


  Differential Expression (24)

Disease log2 FC p
Rheumatoid Arthritis 1.400 0.001
astrocytic glioma -1.900 0.012
ependymoma -1.800 0.023
oligodendroglioma -2.100 0.017
psoriasis 1.800 0.000
osteosarcoma -2.506 0.000
atypical teratoid / rhabdoid tumor -1.700 0.000
medulloblastoma -1.300 0.000
medulloblastoma, large-cell -1.700 0.000
primitive neuroectodermal tumor -1.200 0.035
juvenile dermatomyositis 1.157 0.000
tuberculosis and treatment for 3 months -1.200 0.001
non-small cell lung cancer 1.353 0.000
lung cancer 1.500 0.001
cystic fibrosis -1.100 0.000
adult high grade glioma -1.300 0.001
lung adenocarcinoma 1.079 0.000
non-inflammatory breast cancer 1.200 0.012
breast carcinoma 1.500 0.000
Pick disease -1.500 0.000
ductal carcinoma in situ 1.200 0.014
invasive ductal carcinoma 2.500 0.004
ovarian cancer -4.600 0.000
pituitary cancer -1.100 0.000


Accession O00214 O15215 Q5T3P5 Q5T3Q4 Q8TEV1 Q96B92 Q9BXC8 Q9H584 Q9H585 Q9UEZ6 Q9UP32 Q9UP33 Q9UP34 Gal-8
Symbols Gal-8


PANTHER Protein Class (1)


2YRO   2YV8   2YXS   3AP4   3AP5   3AP6   3AP7   3AP9   3APB   3OJB   3VKL   3VKM   3VKN   3VKO   4BMB   4BME   4FQZ   4GXL   4HAN  

Gene RIF (43)

27066737 this study uncovers a unique molecular mechanism of lymphangiogenesis in which galectin-8-dependent crosstalk among VEGF-C, podoplanin and integrin pathways plays a key role.
25800007 Platelet-derived factor V/Va is generated following endocytosis of the plasma-derived molecule by the platelet precursor cells, megakaryocytes, via a two receptor system consisting of LRP-1 and an unidentified specific "binding site".
25573487 The fundamental roles of galectin-8 in human anaplastic large cell lymphoma
25499921 Gal-8 expression is a potential independent unfavorable prognostic indicator for postoperative recurrence of patients with localized pT1 clear cell renal cell carcinoma
24957054 these results not only confirm the pro-inflammatory role we have already proposed for Gal-8 in other cellular systems but also suggest that this lectin is orchestrating the interaction between leukocytes, platelets and endothelial cells
24939370 The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis
24788652 Whereas Galectin (Gal)-1, -3, and -8 triggered vascular endothelial growth factor (VEGF) release, only Gal-8 induced endostatin secretion.
24696431 We integrate here the available information on Gal-8 expression in different tumor types and attempt to elucidate associations of its expression and localization with tumor progression[review]
24418318 Focusing on the F19Y change in galectin-8, we study of consequences of a single-site substitution in the carbohydrate recognition domain of this family of cellular effectors.
23555773 analysis of how human Galectin-8C domain interacts with its glycan ligands

AA Sequence

AVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW                                     281 - 317

Text Mined References (65)

PMID Year Title
27066737 2016 Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3.
25800007 2015 Mechanisms Regulating Acquisition of Platelet-Derived Factor V/Va by Megakaryocytes.
25573487 2015 Sialylation by ?-galactoside ?-2,6-sialyltransferase and N-glycans regulate cell adhesion and invasion in human anaplastic large cell lymphoma.
25499921 2015 Galectin-8 predicts postoperative recurrence of patients with localized T1 clear cell renal cell carcinoma.
25416956 2014 A proteome-scale map of the human interactome network.
24957054 2014 Galectin-8 elicits pro-inflammatory activities in the endothelium.
24939370 2014 Galectin-8: a matricellular lectin with key roles in angiogenesis.
24788652 2014 Control of angiogenesis by galectins involves the release of platelet-derived proangiogenic factors.
24696431 2014 Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors.
24418318 2014 Natural single amino acid polymorphism (F19Y) in human galectin-8: detection of structural alterations and increased growth-regulatory activity on tumor cells.