Tbio STXBP3 Syntaxin-binding protein 3

Protein Summary

Description

Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.

Uniprot Accession IDs

• O00186
• A8K269
• A8K5K7
• Q53FW1
• Q86YJ3
• Q9UPD7

Gene Name

• STXBP3

Ensembl ID

• ENST00000370008
• ENSP00000359025
• ENSG00000116266

Symbol

• PSP
• MUNC18C
• UNC-18C
• MUNC18-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
biological process	0.77
transcription factor binding site profile	0.74
virus perturbation	0.72
histone modification site profile	0.66

Protein Classes

PANTHER Classes

Protein / Transporter / Syntaxin-binding Protein 3

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Syntaxin-binding Protein 3

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Syntaxin-binding Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.64   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.64   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0