Property Summary

NCBI Gene PubMed Count 76
PubMed Score 129.25
PubTator Score 86.95

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Myocardial Ischemia 169
Disease Target Count P-value
lung carcinoma 2844 2.98266895232026E-19
ependymoma 2514 4.47203779097424E-10
juvenile dermatomyositis 1189 8.76072664556017E-9
medulloblastoma, large-cell 6234 3.09806827713386E-6
pilocytic astrocytoma 3086 6.21099212379203E-6
ovarian cancer 8492 7.0710500337449E-6
Amyotrophic Lateral Sclerosis 432 1.28738217662566E-4
psoriasis 6685 2.93709709468832E-4
Multiple myeloma 1328 3.48138603675529E-4
acute quadriplegic myopathy 1157 5.11140691337371E-4
dermatomyositis 967 6.46049637522586E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 6.79925298764732E-4
osteosarcoma 7933 0.00123018736645666
group 4 medulloblastoma 1875 0.00146273896179252
glioblastoma 5572 0.00153224748256944
Down syndrome 548 0.00164195517388072
atypical teratoid / rhabdoid tumor 4369 0.00240733882883755
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00483338937646976
Waldenstrons macroglobulinemia 765 0.00535994126357511
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00547808988076976
non primary Sjogren syndrome sicca 840 0.00556797625807005
subependymal giant cell astrocytoma 2287 0.00669257484739941
astrocytoma 1493 0.00912735474065052
aldosterone-producing adenoma 664 0.0129476156053914
oligodendroglioma 2849 0.020799686597364
Gaucher disease type 1 171 0.028887693857478
Disease Target Count Z-score Confidence
Tetanus 66 3.842 1.9
Chief cell adenoma 2 3.781 1.9



Accession O00161 O00162 Q13602 Q6IAE3 SNAP-23
Symbols SNAP-23



1NHL   3ZUS  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA Inparanoid

Gene RIF (26)

26733245 Localization of SNAP23 was found in plasma membrane, lipid droplets and mitochondria of skeletal muscle.
26266817 these data suggest that SNAP23 is a key component of the endothelial SNARE machinery that mediates endothelial exocytosis.
24807903 Increased level of SNAP23-Syntaxin4-VAMP7 interaction correlates with decreased Syntaxin4 phosphorylation and trafficking of MT1-MMP to invadopodia during cellular invasion.
24496451 The association of Src, EGFR and beta1 integrin is dependent upon membrane traffic that is mediated by syntaxin13 (officially known as STX12) and SNAP23.
24373201 Data suggest SNAP23 and VAMP3 (vesicle-associated membrane protein 3) participate in interleukin-1beta-, interleukin-1 receptor-, calcium signaling-dependent secretion/exocytosis of interleukin-6 and tumor necrosis factor alpha from synoviocytes.
23087210 Results suggest that phagosomal SNAP-23 is one of the key players regulating the phagosomal environment in macrophages.
21981832 STX-3 and SNAP-23 are crucial for the release of all chemokines in mature human mast cells
21768361 Data show that knockdown of SNAP-23 inhibited the production of virus.
21642540 Introduction of the SNARE domain of SNAP-23 into neutrophils as an HIV transactivator of transcription (TAT) fusion protein significantly inhibits exocytosis of neutrophil granule subsets without altering signal transduction pathway activation.
20519516 SNAP23 and SNAP25 palmitoylation is regulated by DHHC palmitoyl transferases

AA Sequence


Text Mined References (87)

PMID Year Title
26733245 2016 Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria.
26359495 2015 The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs).
26266817 2015 SNAP23 Regulates Endothelial Exocytosis of von Willebrand Factor.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25468996 2014 E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
25416956 2014 A proteome-scale map of the human interactome network.
24807903 2014 SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion.
24705354 2014 The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
24496451 2014 SNARE-dependent interaction of Src, EGFR and ?1 integrin regulates invadopodia formation and tumor cell invasion.
24373201 2014 SNAP-23 and VAMP-3 contribute to the release of IL-6 and TNF? from a human synovial sarcoma cell line.