| Tdark | NTF2-related export protein 2 |
Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export.
The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| astrocytoma | 1146 | 1.7e-19 |
| lung carcinoma | 2843 | 2.0e-17 |
| ependymoma | 4679 | 1.3e-10 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.6e-07 |
| glioblastoma | 5792 | 2.0e-06 |
| pediatric high grade glioma | 1064 | 4.1e-06 |
| medulloblastoma, large-cell | 6241 | 1.6e-05 |
| Astrocytoma, Pilocytic | 3081 | 2.9e-05 |
| osteosarcoma | 7950 | 2.4e-04 |
| primitive neuroectodermal tumor | 3035 | 4.0e-04 |
| medulloblastoma | 720 | 8.2e-04 |
| adrenocortical carcinoma | 1428 | 4.7e-03 |
| Gaucher disease type 3 | 67 | 6.3e-03 |
| ovarian cancer | 8520 | 7.9e-03 |
| oligodendroglioma | 2850 | 2.9e-02 |
| gastric cancer | 459 | 4.2e-02 |
| pancreatic cancer | 2398 | 4.8e-02 |
| pancreatic carcinoma | 562 | 4.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Diversion colitis | 1 | 5.091 | 2.5 |
| Cri-Du-Chat syndrome | 16 | 3.824 | 1.9 |
| non-syndromic X-linked intellectual disability | 20 | 3.596 | 1.8 |
| Motion sickness | 21 | 3.374 | 1.7 |
| Wolf-Hirschhorn syndrome | 32 | 3.373 | 1.7 |
| Pyloric Stenosis | 47 | 3.247 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adrenocortical carcinoma | 1.464 | 4.7e-03 |
| astrocytoma | 1.300 | 1.7e-19 |
| Astrocytoma, Pilocytic | 1.300 | 2.9e-05 |
| atypical teratoid / rhabdoid tumor | 1.700 | 5.6e-07 |
| ependymoma | 1.600 | 1.3e-10 |
| gastric cancer | -1.100 | 4.2e-02 |
| Gaucher disease type 3 | -1.300 | 6.3e-03 |
| glioblastoma | 1.500 | 2.0e-06 |
| lung carcinoma | -1.100 | 2.0e-17 |
| medulloblastoma | 1.200 | 8.2e-04 |
| medulloblastoma, large-cell | 1.400 | 1.6e-05 |
| oligodendroglioma | 1.200 | 2.9e-02 |
| osteosarcoma | 3.539 | 2.4e-04 |
| ovarian cancer | 1.200 | 7.9e-03 |
| pancreatic cancer | -1.100 | 4.8e-02 |
| pancreatic carcinoma | -1.100 | 4.8e-02 |
| pediatric high grade glioma | 1.900 | 4.1e-06 |
| primitive neuroectodermal tumor | 1.100 | 4.0e-04 |
