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Tdark Neurexophilin-2

May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.

 Comments

Property Summary

NCBI Gene PubMed Count 6
PubMed Score 1.03
PubTator Score 34.23

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count
Ovarian Cysts 34
Disease Target Count Z-score Confidence
Male infertility 170 0.0 1.0
substance-related disorder 104 0.0 1.0
Disease Target Count Z-score Confidence
Omphalocele 22 3.811 1.9

Expression

  Differential Expression (3)

Disease log2 FC p
primitive neuroectodermal tumor -1.100 4.4e-03
diabetes mellitus 1.400 1.3e-03
posterior fossa group A ependymoma -1.100 7.9e-06

Synonym

Accession O95156 B7WP24 Q494R1 Q75QC3
Symbols NPH2

Gene

NXPH2

PANTHER Protein Class (1)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (5)

 GO Function (1)

 GO Component (1)

 GO Process (1)

 Compartment GO Term (2)

 HCA RNA Cell Line (21)

See all...

Pathway (1)

Protein-protein Interaction (15)

LRP5   CELSR1   FAT1   FREM2   UBR1   FAT4   ADGRV1   EEF1A2   PCDH7   MADD   UBR2   TAF7   HBA2   NRP2   CELSR2  

AA Sequence 

MRLRPLPLVVVPGLLQLLFCDSKEVVHATEGLDWEDKDAPGTLVGNVVHSRIISPLRLFVKQSPVPKPGP      1 - 70
MAYADSMENFWDWLANITEIQEPLARTKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNG     71 - 140
TFSVYFRHNSTGLGNVSVSLVPPSKVVEFEVSPQSTLETKESKSFNCRIEYEKTDRAKKTALCNFDPSKI    141 - 210
CYQEQTQSHVSWLCSKPFKVICIYIAFYSVDYKLVQKVCPDYNYHSETPYLSSG                    211 - 264
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Text Mined References (7)

PMID Year Title
21956439 2012 Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.
19478329 Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
9570794 1998 Neurexophilins form a conserved family of neuropeptide-like glycoproteins.
8699246 1996 Structure and evolution of neurexophilin.