Property Summary

NCBI Gene PubMed Count 26
PubMed Score 11.17
PubTator Score 23.32

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (12)

Disease log2 FC p
ependymoma -3.100 4.4e-08
medulloblastoma -3.300 5.5e-04
atypical teratoid / rhabdoid tumor -2.900 6.8e-03
glioblastoma -2.700 2.5e-02
medulloblastoma, large-cell -4.400 7.2e-07
adrenocortical carcinoma -3.627 9.2e-06
pilocytic astrocytoma 1.800 3.7e-03
aldosterone-producing adenoma -2.311 2.7e-02
Pick disease -1.100 1.0e-02
ductal carcinoma in situ 2.600 4.6e-02
invasive ductal carcinoma 1.900 4.3e-02
psoriasis -2.100 1.1e-04

Gene RIF (12)

PMID Text
26410934 The role of NXPH1 in in paranoid schizophrenia development in Russians.
24041540 Rs2349775 (NXPH1) and rs17837965 (CDC42) were associated with diarrhoea and constipation predominant irritable bowel syndrome, respectively, in two independent cohorts.
22930747 Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
21734401 Data indicate taht candidate genes ACTB, BZW, OCM, MACC1, NXPH1, PRPS1L1, RAC1 and RPA3, which lie within the DFNB90 region, were sequenced and no potentially causal variants were identified.
21628410 results demonstrate the presence and function of a regulated signaling axis in hematopoiesis centered on NRXN1alpha and its modulation by DAG1 and NXPH1
20877300 Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20732627 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20100581 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20080650 Observational study of gene-disease association. (HuGE Navigator)
12141453 In rat, the secreted ligand for alpha-neurexin, neurexophilin 1, is expressed in the postnatal olfactory bulb.
8699246 In rat, neurexophilin 1 forms a very tight complex with neurexin I alpha.

AA Sequence

MQAACWYVLFLLQPTVYLVTCANLTNGGKSELLKSGSSKSTLKHIWTESSKDLSISRLLSQTFRGKENDT      1 - 70
DLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGK     71 - 140
IVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLC    141 - 210
NYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG             211 - 271
//

Text Mined References (26)

PMID Year Title
26410934 2015 [The Role of Neurotrophins and Neurexins Genes in the Risk of Paranoid Schizophrenia in Russians and Tatars].
24041540 2014 Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.
23544013 2013 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
22930747 2012 Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis.
22890011 2012 Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.
21734401 2011 Novel autosomal recessive nonsyndromic hearing impairment locus DFNB90 maps to 7p22.1-p15.3.
21628410 2011 Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.
20877300 2012 Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.
20732627 2010 Case-control genome-wide association study of attention-deficit/hyperactivity disorder.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20100581 2010 Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort.
20080650 2010 Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.
18762592 2008 Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism.
18464913 2008 A genome-wide association study identifies protein quantitative trait loci (pQTLs).
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12880961 2003 Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.
12853948 2003 The DNA sequence of human chromosome 7.
12690205 2003 Human chromosome 7: DNA sequence and biology.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12141453 2002 Expression of neurexin ligands, the neuroligins and the neurexophilins, in the developing and adult rodent olfactory bulb.
9856994 1998 Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit.
9570794 1998 Neurexophilins form a conserved family of neuropeptide-like glycoproteins.
8699246 1996 Structure and evolution of neurexophilin.