Property Summary

NCBI Gene PubMed Count 50
PubMed Score 37.66
PubTator Score 62.69

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (16)

Disease log2 FC p
malignant mesothelioma -2.600 9.0e-08
psoriasis -2.700 7.6e-05
astrocytoma 1.200 1.6e-13
glioblastoma multiforme 1.400 2.5e-17
pancreatic ductal adenocarcinoma liver m... -1.696 9.7e-03
intraductal papillary-mucinous adenoma (... -3.700 2.8e-04
intraductal papillary-mucinous carcinoma... -4.200 1.5e-04
intraductal papillary-mucinous neoplasm ... -4.600 1.3e-03
lung cancer -2.700 2.4e-06
cystic fibrosis -1.100 6.5e-04
posterior fossa group A ependymoma 1.300 2.5e-03
subependymal giant cell astrocytoma 3.035 3.3e-03
lung carcinoma -1.700 1.7e-11
ovarian cancer -1.100 1.4e-03
pituitary cancer -1.800 4.6e-08
Down syndrome 1.100 2.5e-02

Gene RIF (40)

PMID Text
26617245 Nupr1 acts as a gene modifier of the effect of Kras(G12D)-induced senescence by regulating Dnmt1 expression and consequently genome-wide levels of DNA methylation.
26392315 Hepatitis B virus X (HBx) protein can modulate NUPR1 expression through the Smad4 pathway and NUPR1 has a role in hepatocellular carcinoma progression.
26173068 Mitochondrial respiratory defects and subsequent retrograde signaling, particularly the NUPR1-granulin pathway, play pivotal roles in liver cancer progression
26062422 Knockdown of Nupr1 inhibited the proliferation and migration of HepG2 hepatocellular carcinoma cells
25924802 Increase of NUPR1 protein expression is associated with endometrial cancer invasion.
25899918 Functional characterization of NUPR1L as a new p53-induced gene, which negatively regulates the protumoral factor NUPR1.
25126861 P8 and MEG3 mRNA levels were significantly lower in nonfunctioning and corticotroph adenomas compared with normal pituitary.
25056123 NUPR1 has been conserved throughout evolution, and over time it has undergone duplications and transpositions to form other transcriptional regulators.
24497499 Stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes.
24205110 The Nupr1 protein bound to chemically-damaged-DNA with a slightly larger affinity (0.4 microM), but in an enthalpically-driven process. Nupr1 showed different interacting regions in the formed complexes with Nupr1 or DNA
23443904 COM1 is a potential tumour suppressor in human bladder cancer.
23047430 NUPR1 negatively regulates autophagy-mediated cell death via AURKA, in line with the idea of a tumor suppressor role of autophagy in cancer.
22961798 NUPR1 gene represents a promising target for gene silencing therapy in nonsmall cell lung cancer.
22938721 The simultaneous gain of NUPR1 and ERBB2 can be a significant predictor of poor prognosis in early-stage breast cancers.
22899799 Our data reveal that Nupr1 is involved in a defense mechanism that promotes pancreatic cancer cell survival when exposed to metabolic stress
22858377 findings elucidate a NUPR1-PI-3-K/Akt-phospho-p21 axis that functions in p53-negative, inflammatory breast cancer cells to enhance chemoresistance
22821859 These data indicate a protective role for homotypic cell cannibalism in pancreatic adenocarcinoma and identifies Nupr1 as a molecular regulator of this process.
22565310 a NUPR1/RELB/IER3 stress-related pathway that is required for oncogenic Kras(G12D)-dependent transformation of the pancreas.
22493353 COM-1 is an anti-apoptotic gene and a cell growth promoter. Furthermore, the PPARgamma agonist could increase the inhibitory effect seen in COM-1 knock-down cell growth and to promote apoptosis
21344397 p8 expression controls pancreatic cancer cell migration, invasion and adhesion, three processes required for metastasis, at least in part, through CDC42, a major regulator of cytoskeleton organization.
20890585 Studies indicate that in pancreatic cancer, high levels of p8 protein expression correlate with low apoptosis.
20335521 COM-1, although overexpressed at the messenger level, appears to be distributed in a cytoplasmic fashion at the protein level in tumours.
20181828 A role for the transcriptional regulator p8 in autophagy, is demonstrated.
19946894 Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4
19942374 Role played by a pivotal actor of the cell stress response, the p8 protein, during carcinogenesis.
19650074 MSL1 plays an important role in mediating irradiation-induced DNA repair through formation of HAT complexes and interaction with 53BP1. P8 acts as a negative regulator of this process by interacting with MSL1 and preventing its role on HAT activity.
19153668 nuclear protein 1 (NUPR1) has a role in cancer progression [review]
18690848 Upregulation of NUPR1 is associated with aggressive breast cancer.
17116693 These results identify an unexpectedly broad involvement for p8 in key cellular events linked to cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloproteases production, both of which occur in heart failure.
17101797 SYT-SSX1 fusion protein directly down-regulated the expression of COM1, a regulator of cell proliferation.
17016631 Com-1/p8 is a potential tumour suppressor in human prostate cancer.
16628001 the anti-apoptotic effect previously attributed separately to p8 and prothymosin alpha is in fact borne by the p8/ProTalpha complex, the two proteins being individually inactive
16478804 Antiapoptotic response of cells requires expression of both p8 and ProTalpha.
16300740 The knock-down of p8 expression results in a strong inhibition of Jab1 activity.
16294328 The results suggest that p8 growth stage-dependent localization is regulated by acetylation, that p8 is not free within the cell but forming part of a complex and that it may exert a role in both subcellular localizations.
16101158 p8 expression plays an important role in the progression of medullary thyroid carcinoma, but does not have an anti-apoptotic function.
15854263 CCM1 gene mutation of 1292delAT may contribute to cerebral cavernous malformations.
15781258 The fate of Com-1 can be dually regulated by oestrogen and ubiquitin pathway
12174869 clinical and cell line specific expression identified in experimental central nervous system metastases
11940591 The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.

AA Sequence

MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKGRTKREAAANTNRPSPGGHERKLVTKL      1 - 70
QNSERKKRGARR                                                               71 - 82
//

Text Mined References (53)

PMID Year Title
26617245 2015 Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.
26392315 2015 Hepatitis B virus X promotes hepatocellular carcinoma development via nuclear protein 1 pathway.
26173068 2015 Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression.
26062422 2015 [Nuclear protein 1 knockdown inhibits proliferation and migration of HepG2 cells].
25924802 2015 Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion.
25899918 2015 Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1.
25201988 2014 Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
25126861 2014 Expression analysis of GADD45?, MEG3, and p8 in pituitary adenomas.
25056123 2014 Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins.
24497499 2014 Brief report: stress-inducible nuclear protein 1 regulates matrix metalloproteinase 13 expression in human articular chondrocytes.
24205110 2013 Deciphering the binding between Nupr1 and MSL1 and their DNA-repairing activity.
23443904 2013 Candidate of metastasis 1 regulates in vitro growth and invasion of bladder cancer cells.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
23047430 2013 NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells.
22961798 2012 Lentivirus-mediated RNAi knockdown of NUPR1 inhibits human nonsmall cell lung cancer growth in vitro and in vivo.
22938721 2012 Simultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer.
22899799 2012 Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.
22858377 2012 Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance.
22821859 2012 Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer.
22565310 2012 Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.
22493353 2012 COM-1/p8 acts as a tumour growth enhancer in colorectal cancer cell lines.
21344397 2011 p8 expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesis.
20890585 2010 Stress proteins and pancreatic cancer metastasis.
20335521 The transcript expression and protein distribution pattern in human colorectal carcinoma reveal a pivotal role of COM-1/p8 as a tumour suppressor.
20181828 2010 Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.
19946894 2009 Nuclear protein 1 induced by ATF4 in response to various stressors acts as a positive regulator on the transcriptional activation of ATF4.
19942374 2011 [Role of the stress protein p8 in tumor progression and development of metastasis].
19915574 2009 Common variants at five new loci associated with early-onset inflammatory bowel disease.
19650074 2009 p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage.
19153668 2009 Emerging role of nuclear protein 1 (NUPR1) in cancer biology.
18690848 2008 NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stress.
17116693 2007 Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction.
17101797 2007 The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
17016631 2006 Com-1/p8 acts as a putative tumour suppressor in prostate cancer.
16628001 2006 p8 and prothymosin alpha: unity is strength.
16478804 2006 Regulation of apoptosis by the p8/prothymosin alpha complex.
16341674 2005 Transcriptome analysis of human gastric cancer.
16300740 2006 Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation.
16294328 2006 Cell growth-dependent subcellular localization of p8.
16101158 Expression of p8 protein in medullary thyroid carcinoma.
15854263 2005 A novel gene mutation (1292 deletion) in a Chinese family with cerebral cavernous malformations.
15781258 2005 Com-1/P8 in oestrogen regulated growth of breast cancer cells, the ER-beta connection.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12174869 Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases.
11940591 2002 The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter.
11056169 2001 Human p8 is a HMG-I/Y-like protein with DNA binding activity enhanced by phosphorylation.
10493829 1999 Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.
10493524 1999 Expression of a novel factor in human breast cancer cells with metastatic potential.
10092851 1999 Cloning and expression of the human p8, a nuclear protein with mitogenic activity.
9405444 1997 Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth.