| Tdark | Nucleoporin Nup43 |
Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]
Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004 [PubMed 15146057]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 1.4e-06 |
| malignant mesothelioma | 3232 | 5.8e-06 |
| lung cancer | 4740 | 2.2e-05 |
| ovarian cancer | 8520 | 7.6e-05 |
| dermatomyositis | 966 | 2.9e-04 |
| osteosarcoma | 7950 | 9.0e-04 |
| group 3 medulloblastoma | 4104 | 2.4e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.1e-02 |
| Disease | log2 FC | p |
|---|---|---|
| dermatomyositis | 1.100 | 2.9e-04 |
| group 3 medulloblastoma | 1.400 | 2.4e-03 |
| lung cancer | 2.000 | 2.2e-05 |
| malignant mesothelioma | 1.200 | 5.8e-06 |
| osteosarcoma | -1.069 | 9.0e-04 |
| ovarian cancer | -1.200 | 7.6e-05 |
| pancreatic ductal adenocarcinoma liver m... | 1.407 | 2.1e-02 |
| psoriasis | -1.100 | 1.4e-06 |
MEEIYAKFVSQKISKTRWRPLPPGSLQTAETFATGSWDNEENYISLWSIGDFGNLDSDGGFEGDHQLLCD 1 - 70 IRHHGDVMDLQFFDQERIVAASSTGCVTVFLHHPNNQTLSVNQQWTTAHYHTGPGSPSYSSAPCTGVVCN 71 - 140 NPEIVTVGEDGRINLFRADHKEAVRTIDNADSSTLHAVTFLRTPEILTVNSIGQLKIWDFRQQGNEPSQI 141 - 210 LSLTGDRVPLHCVDRHPNQQHVVATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTC 211 - 280 SEDGSLWHWDASTDVPEKSSLFHQGGRSSTFLSHSISNQANVHQSVISSWLSTDPAKDRIEITSLLPSRS 281 - 350 LSVNTLDVLGPCLVCGTDAEAIYVTRHLFS 351 - 380 //
