| Tbio | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha |
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]
This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6685 | 6.2e-29 |
| atypical teratoid / rhabdoid tumor | 4369 | 4.0e-04 |
| sonic hedgehog group medulloblastoma | 1482 | 4.4e-04 |
| osteosarcoma | 7933 | 5.2e-04 |
| Breast cancer | 3098 | 9.9e-04 |
| glioblastoma | 5572 | 1.3e-02 |
| medulloblastoma, large-cell | 6234 | 1.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Addison's disease | 29 | 5.392 | 2.7 |
| Hypoparathyroidism | 29 | 3.938 | 2.0 |
| Hypersensitivity reaction type II disease | 235 | 3.821 | 1.9 |
| Candidiasis | 48 | 3.567 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 1.186 | 5.2e-04 |
| atypical teratoid / rhabdoid tumor | -1.100 | 4.0e-04 |
| glioblastoma | -1.100 | 1.3e-02 |
| medulloblastoma, large-cell | -1.200 | 1.5e-02 |
| sonic hedgehog group medulloblastoma | 1.100 | 4.4e-04 |
| Breast cancer | -1.400 | 9.9e-04 |
| psoriasis | -1.200 | 6.2e-29 |
| PMID | Text | |
|---|---|---|
| 21071540 | Observational study of gene-disease association. (HuGE Navigator) | |
| 20564319 | Meta-analysis of gene-disease association. (HuGE Navigator) | |
| 12121577 | Cloning and characterisation of NUDT10 as a diadenosine polyphosphate-metabolising Nudix hydrolase. | |
| 12105228 | The NUDT10 gene, located on chromosome X, is preferentially expressed in the testis |
| PMID | Year | Title | |
|---|---|---|---|
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 21269460 | 2011 | Initial characterization of the human central proteome. | |
| 21071540 | 2011 | Validation of genome-wide prostate cancer associations in men of African descent. | |
| 20564319 | 2010 | Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. | |
| 18264098 | 2008 | Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer. | |
| 18264097 | 2008 | Multiple newly identified loci associated with prostate cancer susceptibility. | |
| 17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. | |
| 15772651 | 2005 | The DNA sequence of the human X chromosome. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12370170 | 2002 | Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate. | |
| 12121577 | 2002 | Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases. | |
| 12105228 | 2002 | An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase. |
