| Tbio | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha |
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]
This gene is a member of the nudix (nucleoside diphosphate linked moiety X)-type motif containing family. The encoded protein is a phosphohydrolase and may regulate the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to the regulation of intracellular trafficking. In some populations putative prostate cancer susceptibility alleles have been identified for this gene. Alternatively spliced transcript variants, which differ only in the 5' UTR, have been found for this gene. [provided by RefSeq, Feb 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 6.2e-29 |
| atypical teratoid / rhabdoid tumor | 5112 | 4.0e-04 |
| sonic hedgehog group medulloblastoma | 467 | 4.4e-04 |
| osteosarcoma | 7950 | 5.2e-04 |
| Breast cancer | 3578 | 9.9e-04 |
| glioblastoma | 5792 | 1.3e-02 |
| medulloblastoma, large-cell | 6241 | 1.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Addison's disease | 31 | 5.516 | 2.8 |
| Hypoparathyroidism | 41 | 4.087 | 2.0 |
| Hypersensitivity reaction type II disease | 253 | 3.887 | 1.9 |
| Candidiasis | 55 | 3.533 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.100 | 4.0e-04 |
| Breast cancer | -1.400 | 9.9e-04 |
| glioblastoma | -1.100 | 1.3e-02 |
| medulloblastoma, large-cell | -1.200 | 1.5e-02 |
| osteosarcoma | 1.186 | 5.2e-04 |
| psoriasis | -1.200 | 6.2e-29 |
| sonic hedgehog group medulloblastoma | 1.100 | 4.4e-04 |
