Tbio NTM Neurotrimin

Protein Summary

Description

Neural cell adhesion molecule. This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• Q9P121
• A0MTT2
• Q6UXJ3
• Q86VJ9
• hNT

Gene Name

• NTM

Ensembl ID

• ENST00000374784
• ENSP00000363916
• ENSG00000182667
• ENST00000374786
• ENSP00000363918
• ENST00000374791
• ENSP00000363923
• ENST00000425719
• ENSP00000396722

Symbol

• IGLON2
• NT
• HNT
• NTRI
• CEPU-1
• IGLON2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
virus perturbation	0.83
phenotype	0.81
gene perturbation	0.8
microRNA	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.61   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.61   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0