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Tchem
NT5E
5'-nucleotidase

Protein Summary
Description
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257770
  • ENSP00000257770
  • ENSG00000135318
  • ENST00000369651
  • ENSP00000358665

Symbol
  • NT5
  • NTE
  • NT
  • eN
  • NT5
  • NTE
  • eNT
  • CD73
  • E5NT
  • CALJA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
0.98
small molecule perturbation
0.93
gene perturbation
0.84
biological process
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1620.27   (req: < 5)
Gene RIFs: 228   (req: <= 3)
Antibodies: 1134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1620.27   (req: >= 5)
Gene RIFs: 228   (req: > 3)
Antibodies: 1134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 193
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0