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Tbio
NRL
Neural retina-specific leucine zipper protein

Protein Summary
Description
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396995
  • ENSP00000380191
  • ENSG00000129535
  • ENST00000396997
  • ENSP00000380193
  • ENST00000397002
  • ENSP00000380197
  • ENST00000560550
  • ENSP00000452966
  • ENST00000561028
  • ENSP00000454062
  • ENST00000642485
  • ENSP00000494928
  • ENSG00000285493
  • ENST00000643394
  • ENSP00000495627
  • ENST00000645740
  • ENSP00000495155
  • ENST00000646526
  • ENSP00000496316
  • ENST00000647376
  • ENSP00000496275

Symbol
  • D14S46E
  • RP27
  • D14S46E
  • NRL-MAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
molecular function
0.86
protein domain
0.85
tissue sample
0.69
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 746.49   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 746.49   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0