| Tbio | Pro-neuregulin-4, membrane-bound isoform |
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 3.0e-07 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 6.4e-03 |
| gastric carcinoma | 807 | 8.2e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Peripheral vascular disease | 87 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| gastric carcinoma | -1.100 | 8.2e-03 |
| mucosa-associated lymphoid tissue lympho... | -1.363 | 6.4e-03 |
| osteosarcoma | -1.427 | 3.0e-07 |
