Tbio NREP Neuronal regeneration-related protein

Protein Summary

Description

May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functions in cellular differentiation (By similarity). Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis (By similarity). Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3 (By similarity). May play a role in the regulation of alveolar generation.

Uniprot Accession IDs

• Q16612
• B2RDN8
• B7Z5D2
• D3DSZ8

Gene Name

• NREP

Ensembl ID

• ENST00000257435
• ENSP00000257435
• ENSG00000134986
• ENST00000379671
• ENSP00000368993
• ENST00000395634
• ENSP00000378996
• ENST00000419114
• ENSP00000399766
• ENST00000446294
• ENSP00000402965
• ENST00000447165
• ENSP00000408839
• ENST00000450761
• ENSP00000416617
• ENST00000453526
• ENSP00000403383
• ENST00000455559
• ENSP00000392559
• ENST00000508870
• ENSP00000427149
• ENST00000509427
• ENSP00000422630

Symbol

• C5orf13
• P311
• P311
• PTZ17
• SEZ17
• D4S114
• C5orf13
• PRO1873

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
PubMedID	0.93
kinase perturbation	0.81
small molecule perturbation	0.75
gene perturbation	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.8   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.8   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0