Tbio NR2C2AP Nuclear receptor 2C2-associated protein

Protein Summary

Description

May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes.

Uniprot Accession IDs

• Q86WQ0
• A6NGP7
• B4DW92

Gene Name

• NR2C2AP

Ensembl ID

• ENST00000331552
• ENSP00000332823
• ENSG00000184162
• ENST00000420605
• ENSP00000402756

Symbol

• TRA16
• TRA16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.65
tissue	0.58
cellular component	0.55
tissue sample	0.55
transcription factor binding site profile	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.16   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.16   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0