Tbio NR2C1 Nuclear receptor subfamily 2 group C member 1

Protein Summary

Description

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation. This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P13056
• A8K5K4
• Q15625
• Q15626

Gene Name

• NR2C1

Ensembl ID

• ENST00000330677
• ENSP00000328843
• ENSG00000120798
• ENST00000333003
• ENSP00000333275
• ENST00000393101
• ENSP00000376813

Symbol

• TR2
• TR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.84
disease perturbation	0.83
virus perturbation	0.83
co-expressed gene	0.79
microRNA	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Nuclear Receptor Subfamily 2 Group C Member 1

Protein / Receptor / Nuclear Receptor Subfamily 2 Group C Member 1

Protein / Nucleic Acid Binding / Nuclear Receptor Subfamily 2 Group C Member 1

Protein / ... / C4 Zinc Finger Nuclear Receptor / Nuclear Receptor Subfamily 2 Group C Member 1

DTO Classes

Protein / Nuclear Receptor / Testicular Receptors / Nuclear Receptor Subfamily 2 Group C Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.72   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 375   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.72   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 375   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0