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Tchem
NQO1
NAD(P)H dehydrogenase [quinone] 1

Protein Summary
Description
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been char ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320623
  • ENSP00000319788
  • ENSG00000181019
  • ENST00000379046
  • ENSP00000368334
  • ENST00000379047
  • ENSP00000368335

Symbol
  • DIA4
  • NMOR1
  • DTD
  • QR1
  • DHQU
  • DIA4
  • NMOR1
  • NMORI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
transcription factor perturbation
1
biological term
0.99
PubMedID
0.96
kinase perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2230.26   (req: < 5)
Gene RIFs: 396   (req: <= 3)
Antibodies: 724   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2230.26   (req: >= 5)
Gene RIFs: 396   (req: > 3)
Antibodies: 724   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 69
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1