Property Summary

NCBI Gene PubMed Count 17
PubMed Score 86.04
PubTator Score 18.77

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
medulloblastoma, large-cell 6234 8.7e-04
Disease Target Count Z-score Confidence
Bronchiolitis 9 3.41 1.7
Pertussis 17 3.245 1.6

Expression

  Differential Expression (1)

Disease log2 FC p
medulloblastoma, large-cell 3.900 8.7e-04

Synonym

Accession Q8N729
Symbols L8
L8C
PPL8
PPNPW

Gene

NPW

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG Inparanoid

Gene RIF (6)

PMID Text
26536090 our data highlight that NPW modulates the CaV1.2 currents via G protein-coupled receptor 7, and the presence of it influences arterial tone.
25270269 these studies indicated an inconsistency between plasma and gastric NPW expression in response to nutrient ingestion, suggesting food induced gastric NPW expression may play a more important role locally
22826747 This review of NPW suggests that study of effects of this peptide may reveal its role in regulating feeding and energy metabolism coupled to leptin levels in the brain.
12959997 Intracerebroventricular administration of NPW23 and NPW30 to free-feeding rats suppressed dark phase and fasting-induced food intake. Possibly NPW functions as an endogenous catabolic signaling molecule in the brain.
12719537 a non-AUG translation initiation site is used to express mouse prepro-Npw
12130646 determined that non-AUG translation initiation is used to express human prepro-NPW

AA Sequence

MAWRPGERGAPASRPRLALLLLLLLLPLPSGAWYKHVASPRYHTVGRAAGLLMGLRRSPYLWRRALRAAA      1 - 70
GPLARDTLSPEPAAREAPLLLPSWVQELWETRRRSSQAGIPVRAPRSPRAPEPALEPESLDFSGAGQRLR     71 - 140
RDVSRPAVDPAANRLGLPCLAPGPF                                                 141 - 165
//

Text Mined References (17)

PMID Year Title
26536090 2015 Modulation of CaV1.2 calcium channel by neuropeptide W regulates vascular myogenic tone via G protein-coupled receptor 7.
25270269 2014 Gastric neuropeptide W is regulated by meal-related nutrients.
22826747 2011 Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering.
18577758 2008 Dissociation of heterotrimeric g proteins in cells.
18240029 2008 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
16847439 2006 Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system.
16394174 2006 Neuropeptide W is present in antral G cells of rat, mouse, and human stomach.
16273281 2005 Neuropeptides B and W enhance the growth of human adrenocortical carcinoma-derived NCI-H295 cells by exerting MAPK p42/p44-mediated proliferogenic and antiapoptotic effects.
15797961 2005 G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.
12959997 2003 A role for neuropeptide W in the regulation of feeding behavior.
12719537 2003 Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12401809 2003 Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.
12130646 2002 Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.
12118011 2002 Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
2834384 1988 Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.