Property Summary

NCBI Gene PubMed Count 14
PubMed Score 27.63
PubTator Score 126.02

Knowledge Summary


No data available


  Differential Expression (18)

Disease log2 FC p
malignant mesothelioma 3.000 6.6e-06
astrocytoma -2.800 1.1e-03
posterior fossa group B ependymoma -3.900 6.7e-10
psoriasis -3.300 3.1e-60
glioblastoma -3.800 8.1e-05
oligodendroglioma -2.600 4.5e-17
medulloblastoma -2.000 8.3e-04
atypical teratoid / rhabdoid tumor -3.400 2.7e-07
medulloblastoma, large-cell -1.300 6.0e-03
primitive neuroectodermal tumor -3.600 3.8e-04
colon cancer -2.600 1.9e-05
pediatric high grade glioma -3.200 3.0e-05
pilocytic astrocytoma -3.200 6.8e-06
subependymal giant cell astrocytoma -4.364 3.4e-03
lung adenocarcinoma 1.300 4.7e-02
lung carcinoma 1.500 5.1e-13
ovarian cancer -1.300 2.0e-06
pituitary cancer -1.300 3.2e-03

Gene RIF (8)

26038830 findings suggest that lower NARP mRNA expression contributes to lower excitatory drive onto parvalbumin interneurons in schizophrenia.
25646694 These results suggest that NPTX1 hypermethylation and consequent mRNA changes might be an important molecular mechanism in lung cancer.
25498504 Taken together, these results demonstrate that NP1 gene is a target of as hypoxia inducible factor-1 alpha and it regulates NP1 expression by binding to hypoxia responsive elements in its promoter region.
25053281 NPTX1 was significantly associated with bipolar disorder.
25029423 Long acting progestin contraceptive-enhanced NPTX1 secretion and reactive oxygen species generation in endometrial stromal cells impair endometrial endothelial cells survival resulting in a loss in vascular integrity.
24529709 NPTX1 binds and inhibits TDGF1, and reduces both Nodal and BMP signaling.
17151277 Neuronal pentraxin 1 transgene is a key factor for the synapse loss, the neurite damage, and the apoptotic neuronal death evoked by amyloid-beta protein, which regulates NP1 expression.
16115696 The purpose of the present study was to assess the toxic effect of taipoxin in SCLC-cell lines and to determine if toxicity correlates to NPR and NP1 and NP2 expression levels.

AA Sequence

TKWTFEACRQIN                                                              421 - 432

Text Mined References (14)

PMID Year Title
26038830 2015 Altered Markers of Cortical ?-Aminobutyric Acid Neuronal Activity in Schizophrenia: Role of the NARP Gene.
25646694 2015 NPTX1 is a novel epigenetic regulation gene and associated with prognosis in lung cancer.
25498504 2015 Neuronal pentraxin 1 expression is regulated by hypoxia inducible factor-1?.
25053281 2015 Analysis of t(9;17)(q33.2;q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder.
25029423 2014 Long-acting progestin-only contraceptives enhance human endometrial stromal cell expressed neuronal pentraxin-1 and reactive oxygen species to promote endothelial cell apoptosis.
24529709 2014 NPTX1 regulates neural lineage specification from human pluripotent stem cells.
17151277 2006 Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16115696 2005 Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10748068 2000 Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2.
8884281 1996 Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization.