Tdark NOL9 Polynucleotide 5'-hydroxyl-kinase NOL9

Protein Summary

Description

Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA.

Uniprot Accession IDs

• Q5SY16
• Q2NL84
• Q4VBY3
• Q6P472
• Q7L4D6
• Q96EE0
• Q9H5L4

Gene Name

• NOL9

Ensembl ID

• ENST00000377705
• ENSP00000366934
• ENSG00000162408

Symbol

• Grc3
• NET6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
histone modification site profile	0.84
kinase perturbation	0.84
transcription factor binding site profile	0.84
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.5   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.5   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0