You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NOL8
Nucleolar protein 8

Protein Summary
Description
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358855
  • ENSP00000351723
  • ENSG00000198000
  • ENST00000442668
  • ENSP00000401177
  • ENST00000535387
  • ENSP00000441300
  • ENST00000542053
  • ENSP00000440709
  • ENST00000545558
  • ENSP00000441140

Symbol
  • C9orf34
  • NOP132
  • NOP132
  • C9orf34
  • bA62C3.3
  • bA62C3.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.92
drug perturbation
0.87
transcription factor perturbation
0.74
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0